Antioxidant activity and inhibition of key enzymes linked to type-2 diabetes and hypertension by azadirachta indica-yogurt

Shori, A.B. and Baba, A.S.H. (2011) Antioxidant activity and inhibition of key enzymes linked to type-2 diabetes and hypertension by azadirachta indica-yogurt. Journal of Saudi Chemical Society. ISSN 13196103

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Abstract

Azadirachta indica is widely used in traditional medicine to treat diabetes and hypertension. In the present study A. indica-yogurt was prepared and refrigerated up to 28 days. pH of A. indica-yogurt was lower whereas total titratable acid (TTA) was higher than plain-yogurt during storage. The total phenolic content (TPC) and antioxidant capacity increased during storage. A. indica-yogurt had highest TPC (74.9 ± 5.1 μgGAE/ml; p < 0.05) on day 28 and DPPH inhibition (53.1 ± 5.0%; p < 0.05) on day 14 compared to plain-yogurt (29.6 ± 1.1 μgGAE/ml and 35.9 ± 5.2%, respectively). The OPA values increased between day 7 and 21 of storage but reduced on the 4th week of storage with values for A. indica-yogurt being higher (p < 0.05) than plain-yogurts. Maximum inhibition of α-amylase (47.4 ± 5.8%), α-glucosidase (15.2 ± 2.5%) and angiotensin-1 converting enzyme (ACE, 48.4 ± 7.2%) by plain-yogurt water extract occurred on day 7, 14 and 0, respectively. A. indica-yogurt water extract increased the inhibition to maximal values for α-glucosidase and ACE on day 14 of storage (15.9 ± 10.1% and 79.70 ± 11.2%, respectively) and for α-amylase on day 21 of storage (54.8 ± 3.2%). A. indica-yogurt has higher TPC, antioxidant activities and enzymes inhibitory effects than plain-yogurt. Thus A. indica-yogurt may have the potential to serve as enhanced functional yogurt with anti-diabetic and anti-hypertension activities. © 2011.

Item Type: Article
Additional Information: Institute of Biological Sciences, Faculty of Science Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA
Uncontrolled Keywords: α-Amylase, α-Glucosidase, Angiotensin-1 converting enzyme, Azadirachta indica, Yogurt
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Science > Institute of Biological Sciences
Depositing User: Miss Malisa Diana
Date Deposited: 04 Jul 2013 04:16
Last Modified: 11 Dec 2013 02:26
URI: http://eprints.um.edu.my/id/eprint/6657

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