Evaluation of microwave-assisted digestion condition for the determination of metals in fish samples by inductively coupled plasma mass spectrometry using experimental designs

Low, K.H. and Abas, M.R. and Zain, S.M. (2012) Evaluation of microwave-assisted digestion condition for the determination of metals in fish samples by inductively coupled plasma mass spectrometry using experimental designs. International Journal of Environmental Analytical Chemistry, 92 (10). pp. 1161-1175. ISSN 03067319

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Abstract

This paper describes the development of a compromised single-stage microwave-assisted digestion condition for multi-element determination in fish samples by inductively coupled plasm: mass spectrometry using experimental designs. A Plackett-Burman design was carried out as a multivariate strategy to investigate the main effects of the following parameter on microwave-assisted nitric acid digestion: microwave irradiation time, ramp time, digestion temperature, microwave power limit and the addition of hydrogen peroxide or hydrochloric acid. The most significant microwave setting parameters (radiation time, ramp and temperature) were further evaluated by response surface methodology under Box-Behnken design, while others were kept constant. The influences of different parameters vary according to metal element, thus the working conditions were established as a compromise within optimum region found for each targeted element which ensures quantitative recoveries and time efficiency. The compromised conditions are: ramp to 185°C in 10.5 min then hold for 14.5 min with 1600W (50%) of microwave power, using reagent mixture composed of 2.5 mL nitric acid, 0.5 mL hydrochloric acid and 7.0 mL water. Good agreements were demonstrated between measured and certified values with respect to DORM-3, DOLT-4 and ECM-CE278 and this method was successfully applied for metals determination in tilapia tissues. © 2012 Copyright Taylor and Francis Group, LLC.

Item Type: Article
Additional Information: Department of Chemistry, Faculty of Science Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA
Uncontrolled Keywords: Box-Behnken, chemometric, digestion, experimental design, fish, metal, microwave, Plackett-Burman, Acid digestion, Box-Behnken design, Certified values, Chemometrices, Inductively-coupled, Main effect, Metal elements, Microwave assisted digestion, Microwave power, Microwave-assisted, Multielement determination, Plackett-Burman designs, Ramp time, Reagent mixture, Response surface methodology, Setting parameters, Single stage, Time efficiencies, Working conditions, Design of experiments, Electromagnetic induction, Hydrochloric acid, Hydrogen peroxide, Inductively coupled plasma mass spectrometry, Metals, Microwave generation, Microwave power transmission, Microwaves, Sludge digestion, Statistics, Tissue, Nitric acid
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science > Dept of Chemistry
Depositing User: Miss Malisa Diana
Date Deposited: 14 May 2013 01:38
Last Modified: 14 May 2013 01:38
URI: http://eprints.um.edu.my/id/eprint/6093

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