Computational studies on the cognate and non-cognate aminoacyl-tRNAs

Monajemi, H. and Abdullah, W.A.T.W. and Zain, S.M. (2011) Computational studies on the cognate and non-cognate aminoacyl-tRNAs. Malaysian Journal of Science, 30 (2). pp. 127-132. ISSN 13943065

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Abstract

Although kinetic proofreading plays a major role in the fidelity of protein synthesis, it only includes the codon-anticodon interaction without considering the amino acid side chain. It is not known whether the ribosome has a specific interaction with the amino acid side chain or if the correctly charged tRNA behaves in such a way that brings this fidelity to protein synthesis process. To answer this question, we performed some preliminary calculations using numerical analysis on the misacylated tRNAs and compared the results with that of the cognate aminoacyl-tRNAs. Due to the large size of the molecule, we used 2-layered ONIOM (QM/MM) calculations. Interestingly, it was observed that only the initiator tRNA, mat has a specific interaction with the amino acid side chain.

Item Type: Article
Additional Information: Department of Chemistry, Faculty of Science Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA
Uncontrolled Keywords: Aminoacyl-tRNA, Protein synthesis, Ribosome
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science > Dept of Chemistry
Depositing User: Miss Malisa Diana
Date Deposited: 14 May 2013 01:26
Last Modified: 14 May 2013 01:26
URI: http://eprints.um.edu.my/id/eprint/6068

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