Ali, Hapipah Mohd and Ismail, E. and Zain, S.M. and Subramaniam, P. and Abdul Halim, S.N. (2006) Synthesis and biological activities of nickel(II) and cadmium(II) complexes of chlorohydroxyacetophenone-nitrobenzoylhydrazone: mechanism for formation of the nickel(II) complex. Malaysian Journal of Science, 25 (1). pp. 99-105. ISSN 1394-3065,
Full text not available from this repository.Abstract
The new Nickel(II) and Cadmium(II) complexes have been prepared in ethanol by template condensation of 4-nitrobenzhydrazide, 5-chloro-2-hydroxyacetophenone and metal acetate in the presence of triethylamine. The IR and UV spectra of the ligand and complexes indicate coordination of ligands to the metal centers. The initial product of the Nickel(II) complex is a square planar compound and upon recrydallization with pyridine, the complex has changed to octahedral geometry with coordination of the solvent molecules. The Schiff base ligand, H 25-Clhap-4-NO 2bh was more sensitive towards the MCF-7 cells (human breast cancer cells) with IC 50 values of 4.5 μg ml -1 than the unsubstituted ligand, H 2hapbh. However upon coordination to nickel, the activity has been reduced to the same level as the positive control drug, tamoxifen. The antioxidant properties of the Schiff base ligand (using the FTC method) exhibited higher activity than vitamin E or quercetine. However the activity is lower than the unsubstituted Schiff base ligand or the commercial antioxidant agent, BHT (butylated hydroxytoluene).
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Additional Information: | Department of Chemistry, Faculty of Science Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA |
| Uncontrolled Keywords: | Antioxidant and cytotoxicity properties, Mechanism, Metal complexes, Schiff base |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculty of Science > Department of Chemistry |
| Depositing User: | Miss Malisa Diana |
| Date Deposited: | 15 Apr 2013 02:50 |
| Last Modified: | 28 Apr 2021 07:01 |
| URI: | http://eprints.um.edu.my/id/eprint/5539 |
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