Synthesis and biological properties of Zinc(II) complexes of some 2-hydroxyacetophenone-benzoylhydrazones

Ali, Hapipah Mohd and Teoh, H.L. and Abdullah, N. and Ismail, E. and Basirun, Wan Jefrey and Zain, S.M. and Subramaniam, P. and Nadiah Abdul Halim, S. (2006) Synthesis and biological properties of Zinc(II) complexes of some 2-hydroxyacetophenone-benzoylhydrazones. Malaysian Journal of Science, 25 (2). pp. 97-106. ISSN 1394-3065

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Abstract

The new zinc(II) complexes have been prepared in ethanol by condensation of 2-hydroxyacetophenone with either benzhydrazide or 3-methoxybenzhydrazide and zinc acetate in the presence of triethylamine. The IR, 1H, 13C NMR and UV-visible data show coordination of hydrazone ligands to the metal centers and the spectroscopic data augur well with the x-ray structures which had been published earlier. The Schiff bases and their complexes were screened for antimicrobial, cytotoxic and antioxidant activities. The anti-microbial activities of the ligands and complexes were evaluated by using plate diffusion method against some gram-positive bacteria, gram-negative bacteria and two fungi. There was growth inhibition exhibited by ligands and zinc(II) complexes against tested bacteria and fungi. The Schiff base, H 2hapbh was cytotoxic with IC 50 10-0 μgml -1 against the MCF-7 (human breast cancer cells) while both zinc(II) dimer complexes were strongly cytotoxic with IC 50 values of 4.5 μgml -1. The Schiff bases and zinc(II) complexes showed higher antioxidant activity than quercetin or vitamin E and is comparable with butylated hydroxytoluene (BHT), a commercially used synthetic antioxidant.

Item Type: Article
Additional Information: Department of Chemistry, Faculty of Science Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA
Uncontrolled Keywords: Antioxidant and antimicrobial activities, Cytotoxicity, Hydrazone Schiff bases, Zinc (II) complexes
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science > Dept of Chemistry
Depositing User: Miss Malisa Diana
Date Deposited: 15 Apr 2013 02:48
Last Modified: 31 Jan 2019 07:23
URI: http://eprints.um.edu.my/id/eprint/5536

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