Synthesis, characterization, electrochemistry and Antimicrobial Activity of Zinc(II) complexes of some hydrazone schiff bases

Hapipah, M.A.; Sharifah Rohaiza, S.O.; Nazri, L.P.M.; Teoh, H.L.; Abdullah, N.; Zain, S.M.; Basirun, W.J.; Subramaniam, P. (2006) Synthesis, characterization, electrochemistry and Antimicrobial Activity of Zinc(II) complexes of some hydrazone schiff bases. Malaysian Journal of Science, 25 (1). pp. 107-114. ISSN 13943065

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Abstract

A series of hydrazone Schiff bases and their zinc(II) complexes have been synthesized, characterized and evaluated for antimicrobial activity. The new zinc(II) complexes have been prepared in ethanol media by a template condensation of hydrazides, with either ketone or aldehyde and zinc(II) acetate in the presence of triethylamine. The IR, 1H and 13C NMR data indicate that the hydrazone ligands are coordinated to zinc metal. The cyclic voltammetry of these zinc complexes exhibited irreversible oxidation peaks. The electro-oxidation of Zn 2(Clhaptch) 2(py) 2 displayed a diffusion-controlled one electron transfer reaction process. The antimicrobial activity of the ligands and complexes were evaluated by plate diffusion method against some gram-positive bacteria, gram-negative bacteria and two fungi. There was growth inhibition exhibited by ligands and zinc(II) complexes against tested bacteria and fungi.

Item Type: Article
Creators:
  1. Hapipah, M.A.(Department of Chemistry, Faculty of Science Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA)
  2. Sharifah Rohaiza, S.O.
  3. Nazri, L.P.M.
  4. Teoh, H.L.
  5. Abdullah, N.
  6. Zain, S.M.
  7. Basirun, W.J.
  8. Subramaniam, P.
Journal or Publication Title: Malaysian Journal of Science
Additional Information: Department of Chemistry, Faculty of Science Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA
Uncontrolled Keywords: Anti-microbial activity, Cyclic voltammetry, Hydrazone Schiff bases, Zinc(II) complexes
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science > Dept of Chemistry
Depositing User: Miss Malisa Diana
Date Deposited: 12 Apr 2013 08:59
Last Modified: 12 Apr 2013 08:59
URI: http://eprints.um.edu.my/id/eprint/5534

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