Three-dimensional flower-like brushite crystals prepared from high internal phase emulsion for drug delivery application

Lim, H. and Kassim, A. and Huang, N. and Khiewc, P. and Chiu, W. (2009) Three-dimensional flower-like brushite crystals prepared from high internal phase emulsion for drug delivery application. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 345 (1-3). pp. 211-218. ISSN 0927-7757

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Abstract

In the present study, three-dimensional brushite crystals were prepared through palm olein-in-water high internal phase emulsion processing route for the first time. X-ray diffraction patterns revealed that the powders possessed brushite crystalline phase with trace amount of hydroxyapatite. Unique morphologies of the brushite crystals were obtained as a result of tailoring the precursor concentration, surfactant concentration and oil volume fraction. These factors governed the rate of nucleation and crystal growth, resulting in flower-like morphologies. The petal-like flakes grew radially from the centre which gave rise to porosity of less than 2 μm. A plausible mechanism of crystal growth is discussed and postulated schematically. Sodium ampicillin, a broad spectrum antibiotic, was loaded into the pores of the crystals, which was subsequently released in vitro. The controlled release ability for up to 14 days indicated the potential of using these brushite crystals as drug delivery agents for localized treatments. © 2009 Elsevier B.V. All rights reserved.

Item Type: Article
Uncontrolled Keywords: Calcium phosphate Drug delivery Electron microscopy High internal phase emulsion Porosity Broad spectrum antibiotics Brushite Controlled release Crystalline phase Drug delivery applications Flower-like High internal phase emulsions In-vitro Localized treatment Palm olein Plausible mechanisms Precursor concentration Surfactant concentrations Trace amounts Calcium Calcium alloys Crystal growth Crystallization Diffraction Emulsification Grain boundaries Holographic interferometry Hydroxyapatite Morphology Sodium Surface active agents Three dimensional X ray powder diffraction Controlled drug delivery ampicillin calcium phosphate dibasic surfactant triolein water article controlled drug release drug delivery system emulsion in vitro study powder priority journal X ray diffraction
Subjects: Q Science > Q Science (General)
Q Science > QC Physics
Divisions: Faculty of Engineering > School of Physics
Depositing User: miss munirah saadom
Date Deposited: 04 Apr 2013 01:37
Last Modified: 11 Feb 2019 09:05
URI: http://eprints.um.edu.my/id/eprint/5370

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