Acceleration of wound healing potential of Benzyl N'-(Indol-3-Ylinethylidene)-Hydrazinecarbodithioate derivatives in experimental rats

Mughrabi, F.F. and Ali, Hapipah Mohd and Khaledi, H. and Ameen, M. and Hashim, H. (2010) Acceleration of wound healing potential of Benzyl N'-(Indol-3-Ylinethylidene)-Hydrazinecarbodithioate derivatives in experimental rats. Research Journal of Applied Sciences, 5 (2). pp. 131-136. ISSN 1815-932X

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Abstract

The effects of topical application of Benzyl N'-(indol-3-Ylmethylidene)-Hydrazinecarbodithioate derivatives (BHC) on the process of wound healing enclosure and histology of healed wound were assessed. Five groups of adult male Sprague Dawley rats, all animals were experimentally wound in the posterior neck area About 0.2 rnL of 10% Tween 20 solution was applied to the wound of Group 1 animals (negative control). Intrasitegel was applied topically to wounds of Group 2 animals as reference. About 0.2 mL of 25, 50 and 100 mg mL -1 of compound derivative were applied to the wounds of Group 3, 4 and 5, respectively. Macroscopically, wound dressed with compound derivative significantly healed earlier than those treated with 10% Tween 20 solution. Also wound dressed with 100 mg mL -1 compound derivative accelerate the rate of wound healing compared to those dressed with Intrasite and 25 and 50 mg mL -1 compound derivative. Histological analysis of healed wounds dresses with compound derivative showed comparatively less scar width at wound enclosure and healed wound contained less macrophages and large amount of collagen with angiogenesis compared to wounds dressed with 10% Tween 20 solution. In conclusion, wounds dressed with 100 mg mL -1 of compound derivative significantly enhanced the acceleration of the rate of wound healing enclosure and histologically healed wounds contain comparatively less macrophages and more collagen with angiogenesis. © Medwell Journals, 2010.

Item Type: Article
Additional Information: Department of Chemistry, Faculty of Science Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA
Uncontrolled Keywords: Benzyl N'-(indol-3-ylmethylidene)-hydrazinecarbodithioate derivatives; Histology; Intrasitegel; Placebo; Tween 20; Wound healing
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science > Dept of Chemistry
Depositing User: Miss Malisa Diana
Date Deposited: 01 Apr 2013 02:32
Last Modified: 29 Jan 2019 09:08
URI: http://eprints.um.edu.my/id/eprint/5315

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