Antioxidant, cytotoxic activities, and structure-activity relationship of gallic acid-based indole derivatives

Khaledi, H. and Alhadi, A.A. and Yehye, W.A. and Ali, Hapipah Mohd and Abdulla, Mahmood Ameen and Hassandarvish, P. (2011) Antioxidant, cytotoxic activities, and structure-activity relationship of gallic acid-based indole derivatives. Archiv der Pharmazie / Chemistry in Life Sciences, 344 (11). pp. 703-709. ISSN 0365-6233

Full text not available from this repository. (Request a copy)
Official URL: http://onlinelibrary.wiley.com/doi/10.1002/ardp.20...

Abstract

A new series of gallic hydrazones containing an indole moiety was synthesized through the reaction of gallic hydrazide and different indole carboxaldehydes. Their antioxidant activities were determined on DPPH radical scavenging and inhibition of lipid peroxidation. The in-vitro cytotoxic activities of the compounds were evaluated against HCT-116 (human colon cancer cell line) and MCF-7 (estrogen-dependent human breast cancer cell line) by the MTT method. An attempt to correlate the biological results with their structural characteristics has been done. A limited positive structure activity relationship was found between cytotoxic and antioxidant activities.

Item Type: Article
Additional Information: Department of Chemistry, Faculty of Science Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA
Uncontrolled Keywords: Antioxidant activity; Cytotoxic activity; Gallic hydrazone; Indole
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science > Dept of Chemistry
Depositing User: Miss Malisa Diana
Date Deposited: 21 Mar 2013 03:12
Last Modified: 30 Jan 2019 01:09
URI: http://eprints.um.edu.my/id/eprint/5224

Actions (login required)

View Item View Item