Assessment of in vitro antioxidant, antibacterial and immune activation potentials of aqueous and ethanol extracts of phyllanthus niruri

Amin, Z.A. and Qadir, S.W. and Alshawsh, M.A. and Ali, Hapipah Mohd and Abdulla, M.A. (2012) Assessment of in vitro antioxidant, antibacterial and immune activation potentials of aqueous and ethanol extracts of phyllanthus niruri. Journal of the Science of Food and Agriculture, 92 (9). pp. 1874-1877. ISSN 0022-5142

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Abstract

Background: Recently much attention has been paid to biologically active plants because of their low production cost and fewer adverse effects compared with chemical drugs. In the present investigation the bioactivity of Phyllanthus niruri ethanol and aqueous extracts was evaluated in vitro. Results: The ethanol extract of P. niruri showed a high level of flavonoid content (123.9 ± 0.002 mg g -1), while the aqueous extract showed the highest 2,2-diphenyl-1-picrylhydrazyl (DPPH; IC 506.85 ± 1.80 μmol L -1) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS; 46.44 ± 0.53 μmol L -1) free radical scavenging activities with high phenol content (376 ± 0.02 mg g -1) and elevated levels of ferric reducing antioxidant power (FRAP; 23 883 ± 0.019 mmol g -1) with excellent antibacterial activity against Staphylococcus aureus (20 mm inhibition zone) and Streptococcus agalactiae (12 mm inhibition zone), respectively, in addition to the best immune activation potential of human peripheral blood mononuclear cells (450.5%). Conclusions: It is clear from our results that both extracts of P. niruri has excellent bioactivity roles via elevated levels of antibacterial, antioxidant and percentage of peripheral blood mononuclear cell proliferation, which could lead to the development of medications for clinical use. © 2012 Society of Chemical Industry.

Item Type: Article
Additional Information: Department of Chemistry, Faculty of Science Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA
Uncontrolled Keywords: Antibacterial, Antioxidant, PBMC, Phyllanthus niruri, 1,1 diphenyl 2 picrylhydrazyl, 2,2' azinobis(3 ethylbenzothiazoline 6 sulfonic acid), 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid), 2,2-diphenyl-1-picrylhydrazyl, antiinfective agent, biphenyl derivative, immunological adjuvant, picric acid, plant extract, sulfonic acid derivative, thiazole derivative, article, bacterium, cell proliferation, chemistry, drug effect, human, immunology, metabolism, mononuclear cell, Phyllanthus, Staphylococcus aureus, Streptococcus agalactiae, Adjuvants, Immunologic, Anti-Bacterial Agents, Antioxidants, Bacteria, Biphenyl Compounds, Humans, Leukocytes, Mononuclear, Picrates, Plant Extracts, Sulfonic Acids, Thiazoles
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science > Dept of Chemistry
Depositing User: Miss Malisa Diana
Date Deposited: 19 Mar 2013 00:19
Last Modified: 21 Mar 2019 06:33
URI: http://eprints.um.edu.my/id/eprint/5149

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