Synthesis of 2 '-(5-Chloro-2-Hydroxybenzylidene) benzenesulfanohydrazide schiff base and its anti-ulcer activity in ethanol-induced gastric mucosal lesions in rats

Gwaram, N.S. and Abdulla, M.A. and Ali, Hapipah Mohd and Musalam, L. (2012) Synthesis of 2 '-(5-Chloro-2-Hydroxybenzylidene) benzenesulfanohydrazide schiff base and its anti-ulcer activity in ethanol-induced gastric mucosal lesions in rats. Tropical Journal of Pharmaceutical Research, 11 (2). pp. 251-257. ISSN 1596-5996

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Abstract

Purpose: To study the anti-ulcer activity of 2'-(5-Chloro-2-hydroxybenzylidene) benzenesulfanohydrazide Schiff base against ethanol-induced gastric mucosal lesions in rats. Methods: 2'-(5-Chloro-2-hydroxybenzylidene) benzenesulfano-hydrazide (Cl-BzSO-HAP) was synthesized, and structurally characterized by elemental analysis, FT-IR, H-1-NMR and C-13-NMR. Its preventive activity against ulcer induced by absolute ethanol in Sprague-Dawley rats were studied in vivo. Twenty four Sprague Dawley (SD) rats (12 males and 12 females) were assigned equally into 4 groups (n = 6), including negative control and positive control groups. The third group received a low oral dose of the compound (50 mg/kg) while the fourth group was administered a high oral dose (100 mg/kg). The degree of gastric lesion formation was assessed. Prior to dosing, the animals were fasted overnight. Results: Cl-BzSO-HAP showed significant preventive activity against ulcer induced by absolute ethanol. Oral administration of the compound (both low and high doses) prior to ethanol administration inhibited gastric lesion formation by 88.0 and 94.9%, respectively, compared to 82.7% for the positive control, cimetidine. Conclusion: Extensive gastric necrosis in rats induced by absolute ethanol was prevented by administration of Cl-BzSO-HAP resulting in reduced or total absence of lesions.

Item Type: Article
Additional Information: Department of Chemistry, Faculty of Science Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science > Dept of Chemistry
Depositing User: Miss Malisa Diana
Date Deposited: 18 Mar 2013 03:04
Last Modified: 13 Feb 2019 09:00
URI: http://eprints.um.edu.my/id/eprint/5144

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