Synthesis, structural characterization and in vitro cytotoxicity of diorganotin complexes with schiff base ligands derived from3-hydroxy-2-naphthoylhydrazide

Mun, L.S. and Mun, L.K. and Nurestri, A.M.S. and Shin, S.K. and Hapipah, M.A. (2012) Synthesis, structural characterization and in vitro cytotoxicity of diorganotin complexes with schiff base ligands derived from3-hydroxy-2-naphthoylhydrazide. Applied Organometallic Chemistry, 26 (6). pp. 310-319. ISSN 0268-2605

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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/aoc.286...

Abstract

A series of diorganotin complexes with Schiff base ligands, (E)-N'-(5-bromo-2-hydroxybenzylidene)-3-hydroxy-2-naphthohydrazide, H2L1, and (E)-N'-(5-chloro-2-hydroxybenzylidene)-3-hydroxy-2-naphthohydrazide, H2L2, were synthesized and characterized by elemental analysis, IR, 1H, 13C and 119Sn NMR spectroscopy. The molecular structures of the complexes, [(5-bromo-2-oxidobenzylidene)-3-hydroxy-2-naphthohydrazidato]di(o-chlorobenzyl)tin(IV) 6 and [(5-chloro-2-oxidobenzylidene)-3-hydroxy-2-naphthohydrazidato]dibutyltin(IV) 9, were determined through single-crystal X-ray diffraction and revealed a distorted trigonal-bipyramidal configuration. The in vitro cytotoxic activity of the Schiff bases and their diorganotin complexes was also evaluated against several human carcinoma cell lines, namely HT29 (human colon carcinoma cell line), SKOV-3 (human ovarian cancer cell line), MCF7 (hormone-dependent breast carcinoma cell line) and MRC5 (non-cancer human fibroblast cell line). [(5-Bromo-2-oxidobenzylidene)-3-hydroxy-2-naphthohydrazidato]dibutyltin(IV) 2 and [(5-bromo-2-oxidobenzylidene)-3-hydroxy-2-naphthohydrazidato]dibenzyltin(IV) 5 were the most active diorganotin complexes of H2L1 ligand. Among the diorganotin complexes of H2L2 ligand, [(5-chloro-2-oxidobenzylidene)-3-hydroxy-2-naphthohydrazidato]dicyclohexyltin(IV) 11 showed good cytotoxic activity against all the tested cell lines. As such, the above compounds can be considered agents with potential anticancer activities, and can therefore be investigated further in in vitro or in vivo anticancer studies. Copyright (c) 2012 John Wiley & Sons, Ltd.

Item Type: Article
Additional Information: Department of Chemistry, Faculty of Science Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA
Uncontrolled Keywords: Diorganotin;crystal structures;cytotoxic activity
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science > Dept of Chemistry
Depositing User: Miss Malisa Diana
Date Deposited: 18 Mar 2013 03:46
Last Modified: 23 Feb 2015 13:40
URI: http://eprints.um.edu.my/id/eprint/5137

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