Li, Junxian and Mehrabanian, Mojtaba and Mivehchi, Hassan and Banakar, Morteza and Etajuri, Enas Abdalla (2023) The homeostasis and therapeutic applications of innate and adaptive immune cells in periodontitis. Oral Diseases, 29 (7). pp. 2552-2564. ISSN 1354-523X, DOI https://doi.org/10.1111/odi.14360.
Full text not available from this repository.Abstract
Objectives Periodontitis (PD) is one of the most common dental disorders. This chronic oral inflammation is caused by complicated interrelations between bacterial infections, dysregulated immune reactions, and environmental risk factors. A dysregulated immune response can lead to inflammatory bone resorption by allowing the recruitment of pro-inflammatory immune cells to the periodontal tissues. Subjects The recruitment of innate and adaptive immune cells in PD initiates the acute and following chronic inflammatory processes. The inflamed tissues, on the other hand, can be restored if the anti-inflammatory lineages are predominantly established in the periodontal tissues. Therefore, we aimed to review the published literature to provide an overview of the existing knowledge about the role of immune cells in PD, as well as their possible therapeutic applications. Results Experimental studies showed that drugs/systems that negatively regulate inflammatory cells in the body, as well as interventions aimed at increasing the number of anti-inflammatory cells such as Tregs and Bregs, can both help in the healing process of PD. Conclusion Targeting immune cells or their positive/negative manipulations has been demonstrated to be an effective therapeutic method. However, to use this sort of immunotherapy in humans, further pre-clinical investigations, as well as randomized clinical trials, are required.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | cell therapy; immune cells; immunotherapy; periodontitis |
| Subjects: | R Medicine > RK Dentistry |
| Divisions: | Faculty of Dentistry |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 03 Jul 2025 04:45 |
| Last Modified: | 03 Jul 2025 04:45 |
| URI: | http://eprints.um.edu.my/id/eprint/51023 |
Actions (login required)
 |
View Item |
