Genetic polymorphism of cytochrome P450 2C19 in healthy Malaysian subjects

Yang, Y.S. and Wong, L.P. and Lee, T.C. and Mustafa, A.M. and Mohamed, Z. and Lang, C.C. (2004) Genetic polymorphism of cytochrome P450 2C19 in healthy Malaysian subjects. British Journal of Clinical Pharmacology, 58 (3). pp. 332-335. ISSN 0306-5251

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Abstract

Aims: Impaired S-mephenytoin 4�-hydroxylation is a well-described genetic polymorphism affecting drug metabolism in humans. Although ethnic differences in its distribution of polymorphism has been described, it is not known whether there is an ethnic heterogeneity of the structure and expression of the CYP2C19 enzyme in the Malaysian population. Methods: Study subjects were 142 healthy, unrelated Malaysians aged 18-29 years. Baseline omeprazole and 2-h postingestion omeprazole and 5�-hydroxyomeprazole concentrations were measured for CYP2C19 phenotype determination. Identification of CYP2C19 genotypes was performed with the use of polymerase chain reaction. Results: Phenotyping of CYP2C19 revealed that the prevalence of poor metabolizers (PMs) in the Malaysian population was 14.1, whereas prevalence of PMs in genotyping was 12.6. The PM genotypic prevalence rate was 5.6 in Malays, 19.1 in Chinese and 10.0 in Indian subjects. There were significant differences in PM genotypic prevalence rates among the three primary ethnic groups (P � 0.05). Conclusions: Phenotyping and genotyping revealed significant differences in the prevalence rates among the three ethnic groups in Malaysia, with Chinese recording highest prevalence.

Item Type: Article
Uncontrolled Keywords: Cytochrome P450 2C19 polymorphism Malaysian; 5' hydroxyomeprazole; cytochrome P450 2C19
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms Haslinda Lahuddin
Date Deposited: 19 Apr 2013 01:01
Last Modified: 19 Apr 2013 01:01
URI: http://eprints.um.edu.my/id/eprint/5102

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