Basir, Nurul Fatimah Abdul and Gorjian, Hayedeh and Johan, Mohd Rafie and Khaligh, Nader Ghaffari (2023) Synthesis and characterization of two new 2,5-bis-cycloalkylsulfanyl-1,3,4]thiadiazoles and study of the crystal structure, thermal behavior, and biological activities compared with bismuthiol. Journal of Molecular Structure, 1281. ISSN 0022-2860, DOI https://doi.org/10.1016/j.molstruc.2023.135087.
Full text not available from this repository.Abstract
Two new derivatives of 2,5-bis-cycloalkylsulfanyl-1,3,4]thiadiazoles, i.e., 2,5-bis-cyclopentylsulfanyl-1,3,4]thiadiazole and 2,5-bis-cyclohexylsulfanyl-1,3,4]thiadiazole, were synthesized for a first time through a one-pot two-step procedure through the nucleophilic substitution of the potassium salt of 1,3,4-thiadiazole-2,5-dithiolate with chlorocyclopentane or bromocyclohexane in ethanol under reflux conditions. A cost-effective work-up was applied for the separation and purification of desired products. The products were characterized by physical and spectroscopic techniques. The long colorless needle-like crystals of 2,5-bis-cyclohexylsulfanyl-1,3,4]thiadiazole were obtained, and its crystal structure was stud-ied by single-crystal X-ray diffraction analysis. The transition phases and thermal stability of bismuthiol and two new bis-cycloalkyl bismuthiol were investigated by TGA/DTG and DSC. The thermal decomposi-tion of bismuthiol was reported in the literature; herein, a detailed of its thermal behavior is analyzed for the first time. Finally, the biological activity of bismuthiol and two new bis-cyclopentylsulfanyl and bis-cyclohexylsulfanyl substituted bismuthiol derivatives were screened in vitro against the gram-negative (Escherichia coli ATCC 25922) and gram-positive (Staphylococcus aureus ATCC 25923) bacterial species by the disk diffusion method.(c) 2023 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Funders: | Universiti Malaya, Malaysia (ST018-2022) ; (IIRG004A-2022FNW) |
| Uncontrolled Keywords: | Heterocycles; Crystal structure; Nanostructures; Thermal behavior; Biological activity |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Deputy Vice Chancellor (Research & Innovation) Office > Nanotechnology & Catalysis Research Centre |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 21 Jul 2025 02:31 |
| Last Modified: | 21 Jul 2025 02:31 |
| URI: | http://eprints.um.edu.my/id/eprint/50891 |
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