Khoo, Xin-Hui and Chong, Chun-Wie and Talha, Abdul Malik and Philip, Koshy and Teh, Cindy Shuan-Ju and Isa, Adib Mat and Wong, Mung Seong and Chew, Deborah Chia-Hsin and Wong, Zhiqin and Jusoh, Nor Syarahani and Maksum, Noorhuda Madihah Mohamed and Mokhtar, Norfilza Mohd and Majid, Hazreen Abdul and Ali, Raja Affendi Raja and Lee, Yeong-Yeh and Mahadeva, Sanjiv (2023) The impact of diet and ethnicity on gut microbiota variation in irritable bowel syndrome: A multi-center study. Journal of Gastroenterology and Hepatology, 38 (8). pp. 1259-1268. ISSN 0815-9319, DOI https://doi.org/10.1111/jgh.16174.
Full text not available from this repository.Abstract
Background and AimThe gut microbiota in irritable bowel syndrome (IBS) is known to vary with diet. We aim to (i) analyze the gut microbiota composition of IBS patients from a multi-ethnic population and (ii) explore the impact of a low FODMAP diet on gastrointestinal symptoms and gut microbiota composition among IBS patients. MethodsA multi-center study of multi-ethnic Asian patients with IBS was conducted in two phases: (i) an initial cross-sectional gut microbiota composition study of IBS patients and healthy controls, followed by (ii) a single-arm 6-week dietary interventional study of the IBS patients alone, exploring clinical and gut microbiota changes. ResultsA total of 34 adult IBS patients (IBS sub-types of IBS-D 44.1%, IBS-C 32.4%, and IBS-M 23.5%) and 15 healthy controls were recruited. A greater abundance of Parabacteroides species with lower levels of bacterial fermenters and short-chain fatty acids producers were found among IBS patients compared with healthy controls. Age and ethnicity were found to be associated with gut microbiota composition. Following a low FODMAP dietary intervention, symptom and quality of life improvement were observed in 24 (70.6%) IBS patients. Symptom improvement was associated with adherence to the low FODMAP diet (46.7% poor adherence vs 92.9% good adherence, P = 0.014), and gut microbiota patterns, particularly with a greater abundance of Bifidobacterium longum, Anaerotignum propionicum, and Blautia species post-intervention. ConclusionGut microbiota variation in multi-ethnic IBS patients may be related to dietary intake and may be helpful to identify patients who are likely to respond to a low FODMAP diet.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | diet; ethnicity; gut microbiota; irritable bowel syndrome; the low FODMAP diet |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine > Medical Microbiology Department Faculty of Medicine > Medicine Department Faculty of Medicine > Social & Preventive Medicine Deputy Vice Chancellor (Research & Innovation) Office > Institute of Ocean and Earth Sciences |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 21 Jul 2025 08:32 |
| Last Modified: | 21 Jul 2025 08:32 |
| URI: | http://eprints.um.edu.my/id/eprint/50849 |
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