Ji, Linong and Luo, Yingying and Bee, Yong Mong and Xia, Jun and Nguyen, Khue Thy and Zhao, Weigang and Chen, Liming and Chan, Siew Pheng and Deerochanawong, Chaicharn and Lim, Soo and Yabe, Daisuke and McGill, Margaret and Suastika, Ketut and Li, Xiaoying and Kong, Alice Pik Shan and Chen, Wei and Zhao, Zhan and Xu, Chenchen and Deodat, Marisa and Yao, Xiaomei (2023) Use of basal insulin in the management of adults with type 2 diabetes: An Asia-Pacific evidence-based clinical practice guideline. Journal of Diabetes, 15 (6). pp. 474-487. ISSN 1753-0393, DOI https://doi.org/10.1111/1753-0407.13392.
Full text not available from this repository.Abstract
The objective of this study was to provide recommendations regarding effectiveness, safety, optimal starting dose, optimal maintenance dose range, and target fasting plasma glucose of five basal insulins (glargine U-300, degludec U-100, glargine U-100, detemir, and insulin protamine Hagedorn) in insulin-naive adult patients with type 2 diabetes in the Asia-Pacific region. Based on evidence from a systematic review, we developed an Asia-Pacific clinical practice guideline through comprehensive internal review and external review processes. We set up and used clinical thresholds of trivial, small, moderate, and large effects for different critical and important outcomes in the overall certainty of evidence assessment and balancing the magnitude of intervention effects when making recommendations, following GRADE methods (Grading of Recommendations, Assessment, Development, and Evaluation). The AGREE (Appraisal of Guidelines, Research and Evaluation) and RIGHT (Reporting Items for practice Guidelines in HealThcare) guideline reporting checklists were complied with. After the second-round vote by the working group members, all the recommendations and qualifying statements reached over 75% agreement rates. Among 44 contacted external reviewers, we received 33 clinicians' and one patient's comments. The overall response rate was 77%. To solve the four research questions, we made two strong recommendations, six conditional recommendations, and two qualifying statements. Although the intended users of this guideline focused on clinicians in the Asia-Pacific region, the eligible evidence was based on recent English publications. We believe that the recommendations and the clinical thresholds set up in the guideline can be references for clinicians who take care of patients with type 2 diabetes worldwide.
| Item Type: | Article |
|---|---|
| Funders: | Chinese Geriatric Endocrine Society, Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research (KAKENHI) (23K28017) |
| Uncontrolled Keywords: | Asia-Pacific region; basal insulin; clinical thresholds; evidence-based clinical practice guideline; systematic review; type 2 diabetes |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine > Medicine Department |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 22 Jul 2025 02:06 |
| Last Modified: | 22 Jul 2025 02:06 |
| URI: | http://eprints.um.edu.my/id/eprint/50811 |
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