Ragu, Mohana Eswari and Lim, Joanna Mei Ch'wan and Ng, Pei-Sze and Yip, Cheng-Har and Rajadurai, Pathmanathan and Teo, Soo-Hwang and Pan, Jia-Wern (2023) TP53 somatic mutations in Asian breast cancer are associated with subtype-specific effects. Breast Cancer Research, 25 (1). ISSN 1465-5411, DOI https://doi.org/10.1186/s13058-023-01635-2.
Full text not available from this repository.Abstract
BackgroundRecent genomics studies of breast cancer in Asian cohorts have found a higher prevalence of TP53 mutations in Asian breast cancer patients relative to Caucasian patients. However, the effect of TP53 mutations on Asian breast tumours has not been comprehensively studied.MethodsHere, we report an analysis of 492 breast cancer samples from the Malaysian Breast Cancer cohort where we examined the impact of TP53 somatic mutations in relation to PAM50 subtypes by comparing whole exome and transcriptome data from tumours with mutant and wild-type TP53.ResultsWe found that the magnitude of impact of TP53 somatic mutations appears to vary between different subtypes. TP53 somatic mutations were associated with higher HR deficiency scores as well as greater upregulation of gene expression pathways in luminal A and luminal B tumours compared to the basal-like and Her2-enriched subtypes. The only pathways that were consistently dysregulated when comparing tumours with mutant and wild-type TP53 across different subtypes were the mTORC1 signalling and glycolysis pathways.ConclusionThese results suggest that therapies that target TP53 or other downstream pathways may be more effective against luminal A and B tumours in the Asian population.
| Item Type: | Article |
|---|---|
| Funders: | ACEV Foundation, Estee Lauder Companies, Yayasan Petronas, Yayasan Sime Darby |
| Uncontrolled Keywords: | TP53; Breast cancer; Asian population |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 28 Jul 2025 03:20 |
| Last Modified: | 28 Jul 2025 03:20 |
| URI: | http://eprints.um.edu.my/id/eprint/50806 |
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