Arif, Hajira and Qayyum, Sidra and Akhtar, Wasim and Fatima, Iram and Kayani, Waqas Khan and Rahman, Khursheed Ur and Al-Onazi, Wedad A. and Al-Mohaimeed, Amal M. and Bangash, Naila Khan and Ashraf, Nasra and Razak, Sarah Abdul and Kamal, Asif and Ali, Sajid (2023) Synthesis and Characterization of Zinc Oxide Nanoparticles at Different pH Values from Clinopodium vulgare L. and Their Assessment as an Antimicrobial Agent and Biomedical Application. Micromachines, 14 (7). ISSN 2072-666X, DOI https://doi.org/10.3390/mi14071285.
Full text not available from this repository.Abstract
The current study attempts to evaluate the formation, morphology, and physico-chemical properties of zinc oxide nanoparticles (ZnO NPs) synthesized from Clinopodium vulgare extract at different pH values and to investigate their antimicrobial and biomedical application potential. The reduction of zinc ions to ZnO NPs was determined by UV spectra, which revealed absorption peaks at 390 nm at pH 5 and 348 nm at pH 9, respectively. The spherical morphology of the nanoparticles was observed using scanning electron microscopy (SEM), and the size was 47 nm for pH 5 and 45 nm for pH 9. Fourier-transformed infrared spectroscopy (FTIR) was used to reveal the presence of functional groups on the surface of nanoparticles. The antibacterial activity was examined against Staphylococcus aureus, Streptococcus pyogenes, and Klebsiella pneumonia via the agar-well diffusion method. Comparatively, the highest activities were recorded at pH 9 against all bacterial strains, and among these, biogenic ZnO NPs displayed the maximum inhibition zone (i.e., 20.88 & PLUSMN; 0.79 mm) against S. aureus. ZnO NPs prepared at pH 9 exhibited the highest antifungal activity of 80% at 25 mg/mL and antileishmanial activity of 82% at 400 mg/mL. Altogether, ZnO NPs synthesized at pH 9 show promising antimicrobial potential and could be used for biomedical applications.
| Item Type: | Article |
|---|---|
| Funders: | King Saud University (RSP2023R469) |
| Uncontrolled Keywords: | antimicrobial assay; Clinopodium vulgare; biomedical; pH values; zinc oxide |
| Subjects: | Q Science > Q Science (General) Q Science > QH Natural history |
| Divisions: | Faculty of Science > Institute of Biological Sciences |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 30 Jul 2025 03:26 |
| Last Modified: | 30 Jul 2025 03:26 |
| URI: | http://eprints.um.edu.my/id/eprint/50730 |
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