Padmanabhan, Varun Prasath and Sivashanmugam, Pugalmani and Mubashera, S. M. and Sagadevan, Suresh and Kulandaivelu, Ravichandran (2023) The development of ZnO nanoparticle-embedded graphitic-carbon nitride towards triple-negative breast cancer therapy. RSC Advances, 13 (35). pp. 24333-24342. ISSN 2046-2069, DOI https://doi.org/10.1039/d3ra02887a.
Full text not available from this repository.Abstract
The present study deals with the effects of curcumin-loaded ZnO nanoparticles (NPs) embedded in graphitic-carbon nitride (g-C3N4) sheets for breast cancer cells. The synthesis of these sheets was carried out by a simple co-precipitation method. The physicochemical and thermal properties of the composite sheets were studied using various characterization techniques. The powder X-ray diffraction and high-resolution transmission electron microscopy analyses confirmed the hexagonal wurtzite phase of the ZnO nanoparticles, which were randomly distributed on the g-C3N4 nanosheets, generating a finely bonded interface between the two components. The X-ray photoelectron spectroscopy analysis confirmed the successful formation of the g-C3N4@ZnO composite, while the thermal studies revealed the thermal stability of the composite. In addition, the drug release and kinetics studies proved that the release of curcumin was more significant under acidic conditions (pH 5) compared with neutral pH (7.4). Further, the biological assays verified the antibacterial activity (against two different cultures of E. coli and S. aureus) and anticancer activity (against MDA-MB-231 cancer cells) of the g-C3N4@ZnO/C nanocomposite. Finally, the lactate dehydrogenase activity assay presented the cytotoxic assessment of the nanocomposite based on its cytoplasmic activity and the extent of enzymes released from the damaged cells.
| Item Type: | Article |
|---|---|
| Funders: | Council of Scientific & Industrial Research (CSIR) - India (09/115(0793)/2020 EMR-I) |
| Subjects: | Q Science > QD Chemistry T Technology > TP Chemical technology |
| Divisions: | Deputy Vice Chancellor (Research & Innovation) Office > Nanotechnology & Catalysis Research Centre |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 20 Aug 2025 02:08 |
| Last Modified: | 20 Aug 2025 02:08 |
| URI: | http://eprints.um.edu.my/id/eprint/50687 |
Actions (login required)
 |
View Item |
