Farhan, Nesrain and Al-Maleki, Anis Rageh and Sarih, Norazilawati Muhamad and Yahya, Rosiyah (2023) Synthesis and evaluation of antibacterial activity of transition metal-oleoyl amide complexes. Bioorganic Chemistry, 140. ISSN 0045-2068, DOI https://doi.org/10.1016/j.bioorg.2023.106786.
Full text not available from this repository.Abstract
Recent studies show that some metal ions, injure microbial cells in various ways due to membrane breakdown, protein malfunction, and oxidative stress. Metal complexes are suited for creating novel antibacterial medications due to their distinct mechanisms of action and the variety of three-dimensional geometries they can acquire. In this Perspective, the present study focused on new antibacterial strategies based on metal oleoyl amide complexes. Thus, oleoyl amides ligand (fatty hydroxamic acid and fatty hydrazide hydrate) with the transition metal ions named Ag (I), Co (II), Cu (II), Ni (II) and Sn (II) complexes were successfully synthesized in this study. The metals- oleoyl amide were characterized using elemental analysis, and fourier transforms infrared (FTIR) spectroscopy. The antibacterial effect of metals- oleoyl amide complexes was investigated for Gram-negative bacteria (Escherichia coli) and Gram-positive bacteria (Staphylococcus aureus) by analysing minimum inhibitory concentration (MIC), minimal bactericidal concentration (MBC), and scanning electron microscopy (SEM). The results showed that metal-oleoyl amide complexes have high antibacterial activity at low concentrations. This study inferred that metal oleoyl amide complexes could be utilised as a promising therapeutic antibacterial agent.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Higher Education & Scientific Research (MHESR), Fundamental Research Grant Scheme (FRGS) (FP105-2020) ; (FP052-2016), Universiti Malaya (PG335-2016A) |
| Uncontrolled Keywords: | Transition metals; Metal-fatty hydroxamic acids; Metal-fatty hydrazide hydrate; Antibacterial activity |
| Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry |
| Divisions: | Faculty of Medicine > Medical Microbiology Department Faculty of Science > Department of Chemistry |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 20 Aug 2025 07:10 |
| Last Modified: | 20 Aug 2025 07:10 |
| URI: | http://eprints.um.edu.my/id/eprint/50683 |
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