Nabi, Arshid and Jesudason, Christopher G. and Sabir, Jamal S. M. and Kamli, Majid Rasool (2023) Thermodynamic Insights of the Molecular Interactions of Dopamine (Neurotransmitter) with Anionic Surfactant in Non-Aqueous Media. Pharmaceuticals, 16 (9). ISSN 1424-8247, DOI https://doi.org/10.3390/ph16091187.
Full text not available from this repository.Abstract
This study was aimed at establishing the interactions prevailing in an anionic surfactant, sodium dodecyl sulfate, and dopamine hydrochloride in an alcoholic (ethanol) media by using volumetric, conductometric, and tensiometric techniques. Various methods were utilized to estimate the critical micelle concentration (cmc) values at different temperatures. The entire methods yielded the same cmc values. The corresponding thermodynamic parameters viz. the standard free energy of micellization (Gmico), enthalpy of micellization (Hmico), and entropy of micellization (Smico) were predicted by applying the pseudo-phase separation model. The experimental density data at different temperatures (298.15 K, 303.15 K, 308.15 K, and 313.15 K) were utilized to estimate the apparent molar volumes (V & phi;o) at an infinite dilution, apparent molar volumes (V & phi;cmc) at the critical micelle concentration, and apparent molar volumes (& UDelta;V & phi;m) upon micellization. Various micellar and interfacial parameters, for example, the surface excess concentration (& UGamma;max), standard Gibbs free energy of adsorption at the interface (& UDelta;Goad), and the minimum surface area per molecule (Amin), were appraised using the surface tension data. The results were used to interpret the intermolecular interactions prevailing in the mixed systems under the specified experimental conditions.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | anionic surfactant; critical micelle concentration; thermodynamic properties; drug-surfactant interactions |
| Subjects: | Q Science > QD Chemistry R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Science > Department of Chemistry |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 28 Aug 2025 07:00 |
| Last Modified: | 28 Aug 2025 07:00 |
| URI: | http://eprints.um.edu.my/id/eprint/50666 |
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