Bal, Pavin Kaur and Nah, Shireen Anne and Noor, Wan Mohd Ruzaimie W. A. N. M. O. H. A. M. A. D. and Nor, Mohd Tarmizi M. D. and Singaravel, Srihari and Tan, Wei Sheng and Tan, Yew Wei and Sanmugam, Anand (2023) Suction rectal biopsy (SRB) in Hirschsprung's Disease: Is a single macroscopically adequate sample sufficient? Malaysian Journal of Pathology, 45 (3). pp. 457-462. ISSN 0126-8635,
Full text not available from this repository.Abstract
Hirschsprung's Disease (HD) is a congenital disorder causing severe constipation in infants and children. Suction rectal biopsy (SRB) is the preferred technique for obtaining tissue samples for histopathological evaluation. In low -resource settings like Malaysia, cost-effective diagnostic approaches are necessary, making single sample SRB valuable. This study evaluates the diagnostic accuracy and sufficiency of a single macroscopically adequate sample in suction rectal biopsies for the histopathological confirmation of HD. We conducted a retrospective study of children who underwent suction rectal biopsies for the diagnosis of HD at Hospital Raja Perempuan Zainab II (HRPZII), Kota Bharu, Kelantan. A total of 68 patients were included in the study. The inadequacy rate for bedside SRB was 14%, comparable to current literature. Our study found no statistically significant association between sample inadequacy and gestational age, gender, birth weight, or weight at biopsy. Complication rates were 0%, consistent with literature reports. Calretinin staining, an additional technique, was performed in 23 biopsy episodes, with a 4.3% inadequacy rate, compared to 20% in specimens not subjected to calretinin staining. The cost of SRB almost doubled with each additional sample taken, significant in low -resource environments. In conclusion, single sample SRBs can be adequately diagnostic and cost-effective in low -resource settings, providing valuable insights for healthcare facilities in Malaysia and other developing countries. The use of adjunctive techniques such as calretinin staining may improve diagnostic accuracy while maintaining cost-effectiveness. Further prospective studies with larger sample sizes are needed to validate these findings.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Hirschsprung disease; rectal biopsy; suction rectal biopsy; Rbi2; calretinin |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RB Pathology |
| Divisions: | Faculty of Medicine > Surgery Department |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 11 Sep 2025 07:13 |
| Last Modified: | 11 Sep 2025 07:13 |
| URI: | http://eprints.um.edu.my/id/eprint/50580 |
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