Koike, Hiroshi and Harada, Miyuki and Kusamoto, Akari and Xu, Zixin and Tanaka, Tsurugi and Sakaguchi, Nanoka and Kunitomi, Chisato and Azhary, Jerilee M. K. and Takahashi, Nozomi and Urata, Yoko and Osuga, Yutaka (2023) Roles of endoplasmic reticulum stress in the pathophysiology of polycystic ovary syndrome. Frontiers in Endocrinology, 14. ISSN 1664-2392, DOI https://doi.org/10.3389/fendo.2023.1124405.
Full text not available from this repository.Abstract
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among reproductive-age women, affecting up to 15% of women in this group, and the most common cause of anovulatory infertility. Although its etiology remains unclear, recent research has revealed the critical role of endoplasmic reticulum (ER) stress in the pathophysiology of PCOS. ER stress is defined as a condition in which unfolded or misfolded proteins accumulate in the ER because of an imbalance in the demand for protein folding and the protein-folding capacity of the ER. ER stress results in the activation of several signal transduction cascades, collectively termed the unfolded protein response (UPR), which regulates various cellular activities. In principle, the UPR restores homeostasis and keeps the cell alive. However, if the ER stress cannot be resolved, it induces programmed cell death. ER stress has recently been recognized to play diverse roles in both physiological and pathological conditions of the ovary. In this review, we summarize current knowledge of the roles of ER stress in the pathogenesis of PCOS. ER stress pathways are activated in the ovaries of both a mouse model of PCOS and in humans, and local hyperandrogenism in the follicular microenvironment associated with PCOS is responsible for activating these. The activation of ER stress contributes to the pathophysiology of PCOS through multiple effects in granulosa cells. Finally, we discuss the potential for ER stress to serve as a novel therapeutic target for PCOS.
| Item Type: | Article |
|---|---|
| Funders: | inistry of Education, Culture, Sports, Science and Technology, Japan (MEXT) Japan Society for the Promotion of Science (21j12871) ; (21k16808) ; (22k09614), Japan Society for Menopause and Women's Health (JMWH) |
| Uncontrolled Keywords: | endoplasmic reticulum stress (ER stress); pathophysiology; polycystic ovary syndrome (PCOS); unfolded protein response (UPR); follicular microenvironment; ovary |
| Subjects: | R Medicine > RG Gynecology and obstetrics |
| Divisions: | Faculty of Medicine > Obstetrics & Gynaecology Department |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 18 Sep 2025 07:19 |
| Last Modified: | 18 Sep 2025 07:19 |
| URI: | http://eprints.um.edu.my/id/eprint/50416 |
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