Nasiri, Kamyar and Amiri Moghaddam, Masoud and Etajuri, Enas Abdalla and Badkoobeh, Ashkan and Tavakol, Omid and Rafinejad, Mohammadamin and Forutan Mirhosseini, Armita and Fathi, Amirhossein (2023) Periodontitis and progression of gastrointestinal cancer: Current knowledge and future perspective. Clinical & Translational Oncology, 25 (10). pp. 2801-2811. ISSN 1699-048X, DOI https://doi.org/10.1007/s12094-023-03162-0.
Full text not available from this repository.Abstract
Periodontitis is a polymicrobial disorder caused by dysbiosis. Porphyromonas gingivalis (P.gingivalis) and Fusobacterium nucleatum (F.nucleatum) are pathobiont related to periodontitis pathogenesis and were found to be abundant in the intestinal mucosa of inflammatory bowel disease (IBD) and colorectal cancer (CRC) patients. Besides, periodontal infections have been found in a variety of tissues and organs, indicating that periodontitis is not just an inflammation limited to the oral cavity. Considering the possible translocation of pathobiont from the oral cavity to the gastrointestinal (GI) tract, this study aimed to review the published articles in this field to provide a comprehensive view of the existing knowledge about the relationship between periodontitis and GI malignancies by focusing on the oral/gut axis.
| Item Type: | Article |
|---|---|
| Funders: | None |
| Uncontrolled Keywords: | Colorectal cancer; Periodontitis; IBD; Porphyromonas gingivalis; Malignancy |
| Subjects: | R Medicine > RK Dentistry |
| Divisions: | Faculty of Dentistry > Department of Restorative Dentistry |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 30 Sep 2025 05:50 |
| Last Modified: | 30 Sep 2025 05:50 |
| URI: | http://eprints.um.edu.my/id/eprint/50340 |
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