Thye, Cheow Teng and Hamdan, Mukhri and Sethi, Neha and Rajaratnam, Rajeev Kumar and Hong, Jesrine and Tan, Peng Chiong (2023) Self-monitoring of blood glucose two-weekly versus weekly in gestational diabetes on nutrition therapy: A randomized trial. International Journal of Gynecology & Obstetrics, 163 (2). pp. 601-609. ISSN 0020-7292, DOI https://doi.org/10.1002/ijgo.14861.
Full text not available from this repository.Abstract
ObjectiveTo evaluate 4-point per day self-monitoring of blood glucose (SMBG) every 2 weeks compared with every week. MethodsA total of 104 patients with lifestyle-controlled gestational diabetes (GDMA1) were randomized to 2-weekly or weekly 4-point per day (fasting on awakening and 2-h post-meals) SMBG. Primary outcome was the change in glycated hemoglobin (HbA1c) level from enrollment to 36 weeks of pregnancy across trial arms. The non-inferiority margin was an HbA1c increase of 0.2%. ResultsThe mean difference for change in HbA1c from enrollment to 36 weeks was 0.003% (95% confidence interval CI] -0.098% to +0.093%), within the 0.2% non-inferiority margin. The change in HbA1c level increased significantly within both trial arms-0.275% +/- 0.241% (P < 0.001) in 2-weekly arm versus 0.277% +/- 0.236% (P < 0.001) in the weekly arm. Participants randomized to 2-weekly SMBG were significantly less likely to receive anti-glycemic treatment-5/52 (9.6%) versus 14/50 (28.0%) (relative risk 0.34, 95% CI 0.13-0.88; P = 0.017). All secondary outcomes-maternal weight gain, preterm delivery, cesarean delivery, birthweight, and neonatal admission-were not significantly different. ConclusionsIn GDMA1, 2-weekly is non-inferior to weekly SMBG on the change in HbA1c level. Two-weekly SMBG appeared to be adequate for monitoring women with GDMA1. Clinical Trial RegistrationThis study was registered in ISRCTN registry on March 25, 2022 with trial identification number: ISRCTN13404790 (). The first participant was recruited on April 12, 2022.
| Item Type: | Article |
|---|---|
| Funders: | Department of Obstetrics and Gynecology, Faculty of Medicine, Universiti Malaya (UMSCOG/RF00432022/02) |
| Uncontrolled Keywords: | blood sugar profile; cesarean delivery; diet; gestational diabetes; glycated hemoglobin; HbA1c; self-monitoring blood glucose |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RG Gynecology and obstetrics |
| Divisions: | Faculty of Medicine > Obstetrics & Gynaecology Department Universiti Malaya Medical Centre (UMMC) |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 01 Oct 2025 02:57 |
| Last Modified: | 01 Oct 2025 02:57 |
| URI: | http://eprints.um.edu.my/id/eprint/50304 |
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