Ibrahim, Mohamed Yousif and Hashim, Najihah Mohd and Omer, Fatima Abdelmutaal Ahmed and Abubakar, Muhammad Salisu and Mohammed, Hoyam Adam and Salama, Suzy Munir and Jayash, Soher Nagi (2023) Potential Antitumor Effect of α-Mangostin against Rat Mammary Gland Tumors Induced by LA7 Cells. International Journal of Molecular Sciences, 24 (12). ISSN 1661-6596, DOI https://doi.org/10.3390/ijms241210283.
Full text not available from this repository.Abstract
In this study, the chemotherapeutic effect of a-mangostin (AM) was assessed in rats injected with LA7 cells. Rats received AM orally at 30 and 60 mg/kg twice a week for 4 weeks. Cancer biomarkers such as CEA and CA 15-3 were significantly lower in AM-treated rats. Histopathological evaluations showed that AM protects the rat mammary gland from the carcinogenic effects of LA7 cells. Interestingly, AM decreased lipid peroxidation and increased antioxidant enzymes when compared to the control. Immunohistochemistry results of the untreated rats showed abundant PCNA and fewer p53-positive cells than AM-treated rats. Using the TUNEL test, AM-treated animals had higher apoptotic cell numbers than those untreated. This report revealed that that AM lessened oxidative stress, suppressed proliferation, and minimized LA7-induced mammary carcinogenesis. Therefore, the current study suggests that AM has significant potential for breast cancer treatment.
| Item Type: | Article |
|---|---|
| Funders: | University of Malaya through the Postgraduate Research Fund (PPP) (PG 141-2012B), University Malaya Research Grant (FL001E-13BIO), Ministry of Education, Malaysia (UM-MOHE M.C/625/1/HIR/MOHE//SC/09) |
| Uncontrolled Keywords: | & alpha;-mangostin; mammary cancer; LA7 cells; apoptosis; immunohistochemistry; antioxidant |
| Subjects: | Q Science > Q Science (General) R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica |
| Divisions: | Centre for Natural Products Research and Drug Discovery (CENAR) Faculty of Pharmacy > Department of Pharmaceutical Chemistry |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 01 Oct 2025 03:55 |
| Last Modified: | 01 Oct 2025 03:55 |
| URI: | http://eprints.um.edu.my/id/eprint/50280 |
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