Nordin, Ummu Umaimah Mohd and Ahmad, Noraini and Salim, Norazlinaliza and Tajuddin, Hairul Anuar and Bakar, Noor Fitrah Abu and Narasimhan, Ashwin Kumar (2023) Performance of alkyl β-D-maltosides in molecular self-assembly and formation of oil-in-water nanoemulsions as drug delivery systems. Colloids and Surfaces A-Physicochemical and Engineering Aspects, 674. ISSN 0927-7757, DOI https://doi.org/10.1016/j.colsurfa.2023.131886.
Full text not available from this repository.Abstract
Alkyl beta-D-maltosides are nonionic sugar-based surfactants that can be used as excipients in lipid-based nanoparticles because of their physiological functions and biocompatibility. The self-assembly of alkyl beta-D-maltosides (C-8-C-12) was studied to investigate the effects of alkyl chain length in the binary and ternary systems. Surface tension measurements in the binary systems revealed a synergistic effect on the stability of mixed surfactants with Tween 80 (T80) in the critical aggregation concentration (CAC). Subsequently, formulations of 10:90 wt% oil-in-water (O/W) nanoemulsions (ternary systems) containing T80/alkyl beta-D-maltosides with and without cyclosporine (CsA) as the hydrophobic model drug were characterised by particle size, polydispersity index (PDI), morphology, rheology, and physical stability. The formulations of all nanoemulsion systems were found to be stable against phase separation for 28 days at room temperature. The hydrophobic effect of n-dodecyl-beta-Dmaltoside (DDM, C12) was stronger by enhancing the stability of T80 nanoemulsion in molecular self-assembly compared to the shorter chains of the maltosides. The in vitro drug release study showed that T80/DDM nanoemulsion improved the cumulative release of CsA in 24 h by 98.33 +/- 7.72% compared to T80 nanoemulsion at 83.75 +/- 4.05%. The release of CsA has the highest fit with the Korsmeyer-Peppas kinetic model (R-2 > 0.9), suggesting that CsA is released slowly from the oily core of nanoemulsions to the dissolution medium due to its hydrophobic nature. The cytotoxicity study against 3T3 cells showed that all formulations had no cytotoxicity effect (IC50) up to 500 mu g/mL. The findings demonstrated that T80/DDM nanoemulsion holds great promise as a drug delivery system for the treatment of psoriasis.
| Item Type: | Article |
|---|---|
| Funders: | Fundamental Research Grant Scheme (FRGS/1/2019/STG01/UM/02/7) from the Ministry of Higher Education Malaysia, UM International Collaboration Grant (ST031-2022) |
| Uncontrolled Keywords: | Alkyl maltoside; Sugar-based surfactant; Nanoemulsion; Low energy emulsification method; Cyclosporine |
| Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry |
| Divisions: | Faculty of Science > Department of Chemistry |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 06 Oct 2025 01:57 |
| Last Modified: | 06 Oct 2025 01:57 |
| URI: | http://eprints.um.edu.my/id/eprint/50258 |
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