Li, Ling-Jun and Nahar, Mosammat Nazmun and Du, Ruochen and Chan, Jerry Kok Yen and Tan, June Vic Khi and Eriksson, Johan G. and Wong, Tien Yin and Chan, Shiao-Yng and Su, Lin Lin and Chong, Yap Seng and Zhang, Cuilin (2023) Preconception maternal retinal venular widening and steeper resistance increments in the utero-fetoplacental circulation in pregnancy. iScience, 26 (12). ISSN 2589-0042, DOI https://doi.org/10.1016/j.isci.2023.108535.
Full text not available from this repository.Abstract
We investigated the relationship of preconception maternal retinal vasculature and utero-fetoplacental circulation in ensuing pregnancy. Embedded in a hospital-based, prospective preconception cohort, 396 women with a singleton live birth were included for analysis. We assessed retinal vascular caliber during preconception phase and retrieved ultrasonogram results documenting utero-fetoplacental circulatory indices using Doppler ultrasonography and documented them at 18-21 weeks, 24-28 weeks, and 32-34 weeks where available. We performed a modified Poisson regression to estimate the relative risk of utero-fetoplacental abnormalities, adjusting for major confounders including pre-pregnancy and blood pressure. Per 10 mm increment in maternal preconception retinal venules was associated with over two-fold risks in developing notching (Relative risk RR]: 2.84; 95% confidence interval CI]: 1.79, 4.81) and >= 95th percentile umbilical artery pulsatility index (2.36; 1.72, 3.23) during mid-to-late pregnancy, respectively. Women with preconception retinal venular widening tended to demonstrate steeper resistance increments in both maternal uterine arteries and fetal umbilical arteries during mid-to-late pregnancy.
| Item Type: | Article |
|---|---|
| Funders: | Singapore National Medical Research Council (NMRC) (NMRC/TCR/004-NUS/2008, NMRC/TCR/012-NUHS/2014), Ministry of Health - Singapore National Medical Research Council, Singapore (TA/0027/2014) |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine > Medicine Department |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 28 Oct 2025 08:36 |
| Last Modified: | 28 Oct 2025 08:36 |
| URI: | http://eprints.um.edu.my/id/eprint/50089 |
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