SiouNing, Aileen See and Seong, Tang Swee and Kondo, Hidehiro and Bhassu, Subha (2023) MicroRNA regulation in infectious diseases and its potential as a biosensor in future aquaculture industry: A review. Molecules, 28 (11). ISSN 1420-3049, DOI https://doi.org/10.3390/molecules28114357.
Full text not available from this repository.Abstract
An infectious disease is the most apprehensive problem in aquaculture as it can lead to high mortality in aquatic organisms and massive economic loss. Even though significant progress has been accomplished in therapeutic, prevention, and diagnostic using several potential technologies, more robust inventions and breakthroughs should be achieved to control the spread of infectious diseases. MicroRNA (miRNA) is an endogenous small non-coding RNA that post-transcriptionally regulates the protein-coding genes. It involves various biological regulatory mechanisms in organisms such as cell differentiation, proliferation, immune responses, development, apoptosis, and others. Furthermore, an miRNA also acts as a mediator to either regulate host responses or enhance the replication of diseases during infection. Therefore, the emergence of miRNAs could be potential candidates for the establishment of diagnostic tools for numerous infectious diseases. Interestingly, studies have revealed that miRNAs can be used as biomarkers and biosensors to detect diseases, and can also be used to design vaccines to attenuate pathogens. This review provides an overview of miRNA biogenesis and specifically focuses on its regulation during infection in aquatic organisms, especially on the host immune responses and how miRNAs enhance the replication of pathogens in the organism. In addition to that, we explored the potential applications, including diagnostic methods and treatments, that can be employed in the aquaculture industry.
| Item Type: | Article |
|---|---|
| Funders: | Centre for Research in Biotechnology for Agriculture (CEBAR), University of Malaya[Grant No: ST052-2022 UM], Ministry of Education, Malaysia [Grant No: IIRG002A-2021IISS] |
| Uncontrolled Keywords: | MicroRNA; Infectious diseases; Biomarker; Therapeutics; Biosensor; Aquaculture |
| Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology |
| Divisions: | Faculty of Science > Institute of Biological Sciences Deputy Vice Chancellor (Research & Innovation) Office > Centre for Research in Biotechnology for Agriculture |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 06 Nov 2025 04:39 |
| Last Modified: | 06 Nov 2025 04:39 |
| URI: | http://eprints.um.edu.my/id/eprint/49783 |
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