Chan, Wah-Loong and Chong, Shi-En and Chang, Felicia and Lai, Lee-Lee and Chuah, Kee-Huat and Mustapha, Nik Raihan Nik and Mahadeva, Sanjiv and Chan, Wah-Kheong (2023) Long-term clinical outcomes of adults with metabolic dysfunction-associated fatty liver disease: A single-centre prospective cohort study with baseline liver biopsy. Hepatology International, 17 (4). pp. 870-881. ISSN 1936-0533, DOI https://doi.org/10.1007/s12072-023-10550-9.
Full text not available from this repository.Abstract
BackgroundThere are limited data on the long-term adverse clinical outcomes of adults with metabolic dysfunction-associated fatty liver disease (MAFLD).MethodsThis is a single-centre prospective study of a well-characterized cohort of MAFLD patients who underwent liver biopsy and followed every 6-12 months for adverse clinical outcomes.ResultsThe data for 202 patients were analyzed median age 55.0 (48.0-61.3) years old; male, 47.5%; obese, 88.6%; diabetes mellitus, 71.3%; steatohepatitis, 76.7%; advanced fibrosis, 27.2%]. The median follow-up interval was 7 (4-8) years. The cumulative incidence of liver-related events, cardiovascular events, malignancy and mortality was 0.43, 2.03, 0.60 and 0.60 per 100 person-years of follow-up, respectively. Liver-related events were only seen in patient with advanced fibrosis at 9.1% vs 0% in patient without advanced liver fibrosis (p < 0.001). The cumulative incidence of liver-related events among patients with advanced fibrosis was 1.67 per 100 person-years of follow-up. When further stratified to bridging fibrosis and cirrhosis, the cumulative incidence of liver-related events was 1.47 and 3.85 per 100 person-years of follow-up, respectively. Advanced fibrosis was not significantly associated with cardiovascular events, malignancy or mortality. The cumulative incidence of liver-related events, cardiovascular events, malignancy and mortality were not significantly different between patients with and without steatohepatitis and between obese and non-obese patients. However, liver-related events were only seen among obese patients.ConclusionOverall, the cumulative incidence of liver-related event is low in patients with MAFLD, but it is much higher among those with advanced fibrosis. However, there is a relatively high cumulative incidence of cardiovascular event among patients with MAFLD.
| Item Type: | Article |
|---|---|
| Funders: | University of Malaya Research Grant [Grant No: RG536-13HTM], University of Malaya Special Research Fund [Grant No: BKS067-2017] |
| Uncontrolled Keywords: | MAFLD; Non-alcoholic fatty liver disease; NAFLD; Cardiovascular event; Liver-related event |
| Subjects: | R Medicine > RC Internal medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 06 Nov 2025 04:45 |
| Last Modified: | 06 Nov 2025 04:45 |
| URI: | http://eprints.um.edu.my/id/eprint/49782 |
Actions (login required)
 |
View Item |
