Dwivedi, Khusbu and Mandal, Ashok Kumar and Afzal, Obaid and Altamimi, Abdulmalik Saleh Alfawaz and Sahoo, Ankit and Alossaimi, Manal A. and Almalki, Waleed H. and Alzahrani, Abdulaziz and Abul Barkat, Md. and Almeleebia, Tahani M. and Ullah, Shehla Nasar Mir Najib and Rahman, Mahfoozur (2023) Emergence of Nano-Based Formulations for Effective Delivery of Flavonoids against Topical Infectious Disorders. Gels, 9 (8). ISSN 2310-2861, DOI https://doi.org/10.3390/gels9080671.
Full text not available from this repository.Abstract
Flavonoids are hydroxylated phenolic substances in vegetables, fruits, flowers, seeds, wine, tea, nuts, propolis, and honey. They belong to a versatile category of natural polyphenolic compounds. Their biological function depends on various factors such as their chemical structure, degree of hydroxylation, degree of polymerization conjugation, and substitutions. Flavonoids have gained considerable attention among researchers, as they show a wide range of pharmacological activities, including coronary heart disease prevention, antioxidative, hepatoprotective, anti-inflammatory, free-radical scavenging, anticancer, and anti-atherosclerotic activities. Plants synthesize flavonoid compounds in response to pathogen attacks, and these compounds exhibit potent antimicrobial (antibacterial, antifungal, and antiviral) activity against a wide range of pathogenic microorganisms. However, certain antibacterial flavonoids have the ability to selectively target the cell wall of bacteria and inhibit virulence factors, including biofilm formation. Moreover, some flavonoids are known to reverse antibiotic resistance and enhance the efficacy of existing antibiotic drugs. However, due to their poor solubility in water, flavonoids have limited oral bioavailability. They are quickly metabolized in the gastrointestinal region, which limits their ability to prevent and treat various disorders. The integration of flavonoids into nanomedicine constitutes a viable strategy for achieving efficient cutaneous delivery owing to their favorable encapsulation capacity and diminished toxicity. The utilization of nanoparticles or nanoformulations facilitates drug delivery by targeting the drug to the specific site of action and exhibits excellent physicochemical stability.
| Item Type: | Article |
|---|---|
| Funders: | The authors extend their appreciation to the Deanship of Scientific Research at King Khalid University for funding this work through a large group project under [Grant no. RGP.2/26/44], King Khalid University [Grant no. RGP.2/26/44] |
| Uncontrolled Keywords: | Flavonoids; Nanomedicine; Topical infection; Encapsulation; Drug delivery systems; Nanogel; Hydrogels |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Faculty of Medicine > Department of Pharmacology |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 31 Oct 2025 01:20 |
| Last Modified: | 31 Oct 2025 01:20 |
| URI: | http://eprints.um.edu.my/id/eprint/48673 |
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