Gharanizadeh, Kaveh and Sharifi, Ali Mohammad and Tayyebi, Hamed and Heidari, Razieh and Amiri, Shayan and Noorigaravand, Sajad (2023) Core decompression combined with local DFO administration loaded on polylactic glycolic acid scaffolds for the treatment of osteonecrosis of the femoral head: a pilot study. BMC Pharmacology and Toxicology, 24 (1). ISSN 2050-6511, DOI https://doi.org/10.1186/s40360-023-00682-x.
Full text not available from this repository.Abstract
Background Deferoxamine (DFO) angiogenesis induction potential has been demonstrated in earlier studies, but not in the osteonecrosis of the femoral head (ONFH). In this study, we evaluated the outcome of ONFH treated with combined core decompression and local DFO administration loaded on Polylactic Glycolic Acid (PLGA). Patients and methods In a pilot experimental study, six patients (10 hips) with early-stage non-traumatic ONFH were treated by core decompression, and concurrent injection of local DFO loaded on PLGA scaffold into the subchondral femoral head. Outcome measures were evaluated before the surgery and 12 and 24 months after the surgery and included visual analog scale (VAS) for pain, modified Merle d'Aubigne-Postel (MAP) score for hip function by MRI, and rate of osteonecrosis assessed by the modified. Results The mean MPA score was 14.7 +/- 1.16 before the surgery and 16.7 +/- 1.41 one year after the surgery (P = 0.004). The mean VAS for pain was 4.7 +/- 1.25 before the surgery and 1.8 +/- 1.03 one year after the surgery (P = 0.005). The mean Kerboul angle was 219 +/- 58.64 before the operation and 164.6 +/- 41.82 one year after the operation (P < 0.001). Osteonecrosis progression or collapse was not seen in any of the patients at the final follow-up. No postoperative side effect attributed to the DFO was noticed, as well. Conclusion In short-term follow-up, combined core decompression and local DFO administration not only prevent the progression of ONFH but also reduces the rate of osteonecrosis significantly. However, future controlled studies are required to confirm the present results.
| Item Type: | Article |
|---|---|
| Funders: | None |
| Uncontrolled Keywords: | Osteonecrosis; Femoral head; Core decompression; Deferoxamine; PGLA |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 01 Nov 2025 13:26 |
| Last Modified: | 01 Nov 2025 13:26 |
| URI: | http://eprints.um.edu.my/id/eprint/48641 |
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