Hong, Jin Pyo and Malek, Akramul Zikri Abd and Li, Cheng-Ta and Paik, Jong-Woo and Sulaiman, Ahmad Hatim and Madriaga, Gilbert and Zhuo, Jianmin and Siggins, Sarah and Fu, Dong-Jing and Ju, Po-Chung (2023) Efficacy and safety of esketamine nasal spray in addition to standard of care in patients with major depressive disorder who have active suicidal ideation with intent: A subgroup analysis of the Asian cohort of ASPIRE I (a randomized, double-blind, placebo-controlled study). Asia-Pacific Psychiatry, 15 (4). ISSN 1758-5864, DOI https://doi.org/10.1111/appy.12548.
Full text not available from this repository.Abstract
This post-hoc analysis evaluated the efficacy and safety of intranasal esketamine in the Asian subgroup from ASPIRE I. Patients with major depressive disorder and suicidal ideation with intent received intranasal esketamine (n = 26) or placebo (n = 27), plus standard of care for 25 days. The primary endpoint was the change in Montgomery-Asberg Depression Rating Scale (MADRS) total score from baseline to Day 2. The MADRS score improved in favor of esketamine (least squares mean difference: -3.8). No unexpected safety concerns were noted. The Asian subgroup showed a similar efficacy and safety profile as the total ASPIRE I cohort.
| Item Type: | Article |
|---|---|
| Funders: | Medical writing and editorial support were funded by Janssen Asia Pacific, a division of Johnson and Johnson Pte Ltd, and provided by Tech Observer Asia Pacific Pte Ltd. |
| Uncontrolled Keywords: | Asian; Intranasal esketamine; Major depressive disorder; Suicide |
| Subjects: | B Philosophy. Psychology. Religion > BF Psychology R Medicine > RZ Other systems of medicine > Mental healing |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 01 Nov 2025 14:09 |
| Last Modified: | 01 Nov 2025 14:09 |
| URI: | http://eprints.um.edu.my/id/eprint/48627 |
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