Musa, Kabiru Abubakar and Francis, Jaslene Anne and Mohamad, Saharuddin and Tayyab, Saad (2023) Elucidating the influence of some metal ions on the binding of antimalarial drugs to human serum albumin: spectroscopic approach. Revue Roumaine de Chimie, 68 (10-12). ISSN 0035-3930, DOI https://doi.org/10.33224/rrch.2023.68.10-12.06.
Full text not available from this repository.Abstract
Influence of six metal ions viz. Mg (2+) , K (+) , Ca (2+) , Mn2+ , Cu (2+)and Ba (2+) on the binding affinity of human serum albumin (HSA) towards three antimalarial drugs, namely, sulfadoxine (SDN), mefloquine (MEF) and lumefantrine (LUM) was investigated using fluorescence quenching titrations. The effects of metal ions (Mn (2+) , Cu (2+) and Ba (2+) ) were similar on the affinity of HSA towards SDN, MEF and LUM. Values of the association constant, Ka , for SDN/MEF/LUM - HSA interactions in the presence of these metal ions, decreased significantly in the order: Mn (2+) > Cu (2+) > Ba (2+) . On the other hand, the presence of Mg (2+) , K (+) , and Ca (2+) affected the binding affinity for these drugs differently. Whereas a slight increase in the K a value of the SDN - HSA complex was seen in the presence of Mg (2+) , Ca (2+) produced a similar effect on the LUM - HSA system. For MEF HSA and LUM - HSA systems, effects of K + and Mg (2+) were similar, showing a decrease in the K a value, being more effective with K + ; however, this decrease was more significant than Mn (2+) , Cu (2+) and Ba (2+) . Values of `n' remained approximately equal to 1, hinting at a single binding site for each drug.
| Item Type: | Article |
|---|---|
| Funders: | Petroleum Technology Development Fund, Nigeria PTDF/ED/PHD/MKA/1230/17 |
| Uncontrolled Keywords: | Affinities; Drug |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculty of Science > Institute of Biological Sciences |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 01 Nov 2025 14:25 |
| Last Modified: | 01 Nov 2025 14:25 |
| URI: | http://eprints.um.edu.my/id/eprint/48622 |
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