Wiart, Christophe and Kathirvalu, Geethanjali and Raju, Chandramathi Samudi and Nissapatorn, Veeranoot and Rahmatullah, Mohammed and Paul, Alok K. and Rajagopal, Mogana and Sathiya Seelan, Jaya Seelan and Rusdi, Nor Azizun and Lanting, Scholastica and Sulaiman, Mazdida (2023) Antibacterial and antifungal terpenes from the medicinal angiosperms of Asia and The Pacific: Haystacks and gold needles. Molecules, 28 (9). ISSN 1420-3049, DOI https://doi.org/10.3390/molecules28093873.
Full text not available from this repository.Abstract
This review identifies terpenes isolated from the medicinal Angiosperms of Asia and the Pacific with antibacterial and/or antifungal activities and analyses their distribution, molecular mass, solubility, and modes of action. All data in this review were compiled from Google Scholar, PubMed, Science Direct, Web of Science, ChemSpider, PubChem, and library searches from 1968 to 2022. About 300 antibacterial and/or antifungal terpenes were identified during this period. Terpenes with a MIC <= 2 mu g/mL are mostly amphiphilic and active against Gram-positive bacteria, with a molecular mass ranging from about 150 to 550 g/mol, and a polar surface area around 20 angstrom(2). Carvacrol, celastrol, cuminol, dysoxyhainic acid I, ent-1 beta,14 beta-diacetoxy-7 alpha-hydroxykaur-16-en-15-one, ergosterol-5,8-endoperoxide, geranylgeraniol, gossypol, 16 alpha-hydroxy-cleroda-3,13 (14)Z-diene-15,16-olide, 7-hydroxycadalene, 17-hydroxyjolkinolide B, (20R)-3 beta-hydroxy-24,25,26,27-tetranor-5 alpha cycloartan-23,21-olide, mansonone F, (+)-6,6'-methoxygossypol, polygodial, pristimerin, terpinen-4-ol, and alpha-terpineol are chemical frameworks that could be candidates for the further development of lead antibacterial or antifungal drugs.
| Item Type: | Article |
|---|---|
| Funders: | None |
| Uncontrolled Keywords: | Antibacterial terpenes; Antifungal terpenes; Medicinal plants; Asia; Pacific |
| Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology |
| Divisions: | Faculty of Medicine > Medical Microbiology Department Faculty of Science > Department of Chemistry |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 06 Oct 2025 08:16 |
| Last Modified: | 06 Oct 2025 08:16 |
| URI: | http://eprints.um.edu.my/id/eprint/48298 |
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