Nugroho, Alfarius Eko and Wong, Chin Piow and Hirasawa, Yusuke and Kaneda, Toshio and Tougan, Takahiro and Horii, Toshihiro and Hadi, A. Hamid A. and Morita, Hiroshi (2023) Antimalarial ceramicines Q-T from Chisocheton ceramicus. Journal of Natural Medicines, 77 (3). pp. 596-603. ISSN 1340-3443, DOI https://doi.org/10.1007/s11418-023-01706-w.
Full text not available from this repository.Abstract
Ceramicines are a series of limonoids that were isolated from the bark of Malaysian Chisocheton ceramicus (Meliaceae) and were known to show various biological activity. Four new limonoids, ceramicines Q-T (1-4) were isolated from the barks of C. ceramicus, and their structures were determined on the basis of the 1D and 2D NMR analyses in combination with calculated C-13 chemical shift data. Ceramicines Q-T (1-4) were established to be new limonoids with a cyclopentanonea] phenanthren ring system with a beta-furyl ring at C-17, and without a tetrahydrofuran ring like ceramicine B, which is characteristic of known ceramicines. Ceramicine R (2) exhibited potent antimalarial activity against Plasmodium falciparum 3D7 strain with IC50 value of 2.8 mu M. GRAPHICS] .
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research (KAKENHI) [Grant No: JP 19K07152; JP 22K06671; JP 16K08309] |
| Uncontrolled Keywords: | Ceramicines Q-T; Limonoids; Chisocheton ceramicus; Meliaceae; Antimalarial activity |
| Subjects: | Q Science > QD Chemistry R Medicine > R Medicine (General) R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Faculty of Science > Department of Chemistry |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 06 Oct 2025 12:49 |
| Last Modified: | 06 Oct 2025 12:49 |
| URI: | http://eprints.um.edu.my/id/eprint/48292 |
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