Chuah, Kee-Huat and Black, Christopher J. and Tee, Vincent and Lim, Sze-Zee and Hian, Wen-Xuan and Sahran, Nur-Fazimah and Lee, Yeong-Yeh and Mahadeva, Sanjiv and Ford, Alexander C. (2023) A prospective comparison of UK and Malaysian patients with irritable bowel syndrome in secondary care. Alimentary Pharmacology & Therapeutics, 58 (2). pp. 168-174. ISSN 0269-2813, DOI https://doi.org/10.1111/apt.17567.
Full text not available from this repository.Abstract
Background: The prevalence of irritable bowel syndrome (IBS) is now known to be similar in various geographical regions, but there has been no study directly comparing characteristics of patients with IBS between populations. Aims: To evaluate clinical and psychological differences between adults with IBS seen in secondary care in the United Kingdom (UK) and Malaysia. Methods: Age-and sex-matched patients with IBS from a single centre in the UK (Leeds) and two centres in Malaysia (Kuala Lumpur and Kota Bharu), who fulfilled Rome III criteria, were recruited prospectively. Demographic characteristics and gastrointestinal and psychological symptoms were compared between both groups. Results: A total of 266 (133 UK and 133 Malaysian) age-and sex-matched patients with Rome III IBS were recruited (mean age: 45.1 years Malaysia, vs. 46.5 years UK; 57.9% female). UK patients were more likely to consume alcohol than Malaysian patients (54.1% vs. 10.5%, p < 0.001). Compared with Malaysian patients, UK patients had more frequent abdominal pain, abdominal bloating, meal-related symptoms (p < 0.001 for all), higher symptom scores (mean 268.0 vs 166.0; p < 0.001), greater limitation of activities due to IBS (p = 0.007) and were more likely to report abnormal anxiety scores (p < 0.001). Higher perceived stress (mean 21.3 vs. 19.1, p = 0.014) and gastrointestinal symptom-specific anxiety scores (mean 50.8 vs. 43.0, p < 0.001) were also observed in UK patients. Finally, UK patients had higher somatoform symptom-reporting scores (mean 8.9 vs. 6.9, p < 0.001). Conclusions: IBS is more severe and is associated with a higher level of psychological symptoms in the UK compared with Malaysian patients in secondary care.
| Item Type: | Article |
|---|---|
| Funders: | None |
| Uncontrolled Keywords: | Diagnostic questionnaire; Hospital anxiety; Deprassion |
| Subjects: | R Medicine > RC Internal medicine R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 07 Oct 2025 02:49 |
| Last Modified: | 07 Oct 2025 02:49 |
| URI: | http://eprints.um.edu.my/id/eprint/48249 |
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