Ang, Wei-Shan and Law, Jodi Woan-Fei and Letchumanan, Vengadesh and Hong, Kar Wai and Wong, Sunny Hei and Ab Mutalib, Nurul Syakima and Chan, Kok-Gan and Lee, Learn-Han and Tan, Loh Teng-Hern (2023) A keystone gut bacterium christensenella minuta-a potential biotherapeutic agent for obesity and associated metabolic diseases. Foods, 12 (13). ISSN 2304-8158, DOI https://doi.org/10.3390/foods12132485.
Full text not available from this repository.Abstract
A new next-generation probiotic, Christensenella minuta was first discovered in 2012 from healthy human stool and described under the phylum Firmicutes. C. minuta is a subdominant commensal bacterium with highly heritable properties that exhibits mutual interactions with other heritable microbiomes, and its relative abundance is positively correlated with the lean host phenotype associated with a low BMI index. It has been the subject of numerous studies, owing to its potential health benefits. This article reviews the evidence from various studies of C. minuta interventions using animal models for managing metabolic diseases, such as obesity, inflammatory bowel disease, and type 2 diabetes, characterized by gut microbiota dysbiosis and disruption of host metabolism. Notably, more studies have presented the complex interaction between C. minuta and host metabolism when it comes to metabolic health. Therefore, C. minuta could be a potential candidate for innovative microbiome-based biotherapy via fecal microbiota transplantation or oral administration. However, the detailed underlying mechanism of action requires further investigation.
| Item Type: | Article |
|---|---|
| Funders: | Jeffrey Cheah School of Medicine and Health Sciences under Early Career Researcher Grant [Grant No: ECR-000039] |
| Uncontrolled Keywords: | Christensenella minuta; Next-generation probiotic; Metabolic diseases; Obesity; Inflammatory bowel disease |
| Subjects: | Q Science > Q Science (General) Q Science > QH Natural history |
| Divisions: | Faculty of Science > Institute of Biological Sciences |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 11 Oct 2025 06:52 |
| Last Modified: | 11 Oct 2025 06:52 |
| URI: | http://eprints.um.edu.my/id/eprint/48218 |
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