Lee, Choon Jiat and Lai, Lee Lee and See, Mee Hoong and Velayuthan, Rukumani Devi and Doon, Yoke Kiet and Lim, Phaik Eem and Lim, Crystale Siew Ying and Poong, Sze Wan and Chong, Christina Shook Cheng and Lee, Pui Yuei and Tan, Yong Hui (2023) Breaking the Barrier: A Study on Multi-drug Resistance in Breast Abscess at an Academic Malaysian Hospital. World Journal of Surgery, 47 (11). pp. 2743-2752. ISSN 0364-2313, DOI https://doi.org/10.1007/s00268-023-07108-z.
Full text not available from this repository.Abstract
BackgroundIn recent years, the increase in antibiotics usage locally has led to a worrying emergence of multi-drug resistant organisms (MDRO), with the Malaysian prevalence rate of methicillin-resistant Staphylococcus aureus (MRSA) ranging from 17.2 to 28.1% between 1999 and 2017. A study has shown that 7% of all non-lactational breast abscesses are caused by MRSA. Although aspiration offers less morbidities compared to surgical drainage, about 20% of women infected by MRSA who initially underwent aspiration subsequently require surgical drainage. This study is conducted to determine the link between aetiology, antimicrobial resistance pattern and treatment modalities of breast abscesses.MethodsRetrospective study of reviewing microbiology specimens of breast abscess patients treated at Universiti Malaya Medical Centre from 2015 to 2020. Data collected from microbiology database and electronic medical records were analysed using SPSS V21.ResultA total of 210 specimens from 153 patients were analysed. One-fifth (19.5%) of the specimens isolated were MDRO. Lactational associated infections had the largest proportion of MDR in comparison to non-lactational and secondary infections (38.5%, 21.7%, 25.7%, respectively; p = 0.23). Staphylococcus epidermidis recorded the highest number of MDR (n = 12) followed by S. aureus (n = 8). Adjusted by aetiological groups, the presence of MDRO is linked to failure of single aspirations (p = 0.554) and significantly doubled the risk of undergoing surgical drainage for resolution (p = 0.041).ConclusionMDR in breast abscess should be recognised as an increasing healthcare burden due to a paradigm shift of MDRO and a rise of resistance cases among lactational associated infection that were vulnerable to undergo surgical incision and drainage for resolution.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Higher Education, Malaysia [Grant no. FRGS/1/2021/STG01/UCSI/03/1] |
| Uncontrolled Keywords: | Abscess; Anti-bacterial agents; Female; Hospitals; Humans; methicillin-resistant staphylococcus aureus; Retrospective studies; Staphylococcal infections; Staphylococcus aureus |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RD Surgery R Medicine > RT Nursing |
| Divisions: | Faculty of Medicine > Medical Microbiology Department Faculty of Medicine > Nursing Science Department Faculty of Medicine > Surgery Department Deputy Vice Chancellor (Research & Innovation) Office > Institute of Ocean and Earth Sciences |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 11 Oct 2025 08:54 |
| Last Modified: | 11 Oct 2025 08:54 |
| URI: | http://eprints.um.edu.my/id/eprint/48195 |
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