Yong, Shin Shen and Han, Winn Hui and Choong, R. K. J. and Faheem, Nik Aimee Azizah and Toh, Y. F. and Bee, Ping Chong and Kwan, Zhenli (2023) Case series of cutaneous graft-versus-host disease (GVHD) in patients receiving haematopoietic stem cell transplantation in a tertiary Malaysian hospital. Hong Kong Journal of Dermatology and Venereology, 31 (1). pp. 5-13. ISSN 1814-7453,
Full text not available from this repository.Abstract
Introduction: Acute and chronic graft-versus-host disease (GVHD) are multisystem disorders which are complications of haematopoietic stem cell transplant (HSCT). It is important to consider other differential diagnoses that may have similar clinical and histopathologic features as GVHD. Method: A retrospective analysis was conducted on adult patients from a single centre who developed GVHD after HSCT between January 2014 and June 2018. Results: Fourteen patients were included where 13 had acute GVHD and 1 had chronic GVHD. The median age was 35.0 years (IQR 26 to 44 years) while median onset of cutaneous symptoms for acute GVHD was 70 days (IQR 17.0 - 96.5 days). All cases had histopathological confirmation. For acute GVHD (n=13), classical presentation with generalised exanthem and perifollicular erythema is the commonest (84.6%, n=11), where 61.5% and 38.5% of patients had stage 2 and 3 extent of skin involvement, respectively (n=8, n=5). 76.9% (n=10) of patients with acute GVHD had other organs involvement, such as liver, eyes, and gut. Lerner's grade 2 was the most common histological grade for patients with acute GVHD (53.8%, n=7) followed by grade 1 (38.5%, n=5). One patient with chronic GVHD had lichen planus-like presentation. All patients had received various antibiotics within two months prior to onset. None of the skin biopsies showed significant eosinophilic infiltrates. Conclusion: Cutaneous manifestations of GVHD are among the earliest presenting complaints among patients who have undergone HSCT. Half of these patients only had skin GVHD without any other organs involvement. Hence, biopsy is important to confirm the diagnosis of GVHD along with clinical correlation.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Graft versus host disease; Haematopoietic stem cell transplant; Histopathology of GVHD; Skin biopsy for GVHD |
| Subjects: | R Medicine > RB Pathology |
| Divisions: | Faculty of Medicine > Medicine Department Faculty of Medicine > Pathology Department |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 18 Oct 2025 06:28 |
| Last Modified: | 18 Oct 2025 06:28 |
| URI: | http://eprints.um.edu.my/id/eprint/48164 |
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