Vardar, Elif and Nam, Hui Yin and Vythilingam, Ganesh and Tan, Han Ling and Mohamad Wali, Haryanti Azura and Engelhardt, Eva-Maria and Kamarul, Tunku and Zambelli, Pierre-Yves and Samara, Eleftheria (2023) A New Bioactive Fibrin Formulation Provided Superior Cartilage Regeneration in a Caprine Model. International Journal of Molecular Sciences, 24 (23). ISSN 1661-6596, DOI https://doi.org/10.3390/ijms242316945.
Full text not available from this repository.Abstract
The effective and long-term treatment of cartilage defects is an unmet need among patients worldwide. In the past, several synthetic and natural biomaterials have been designed to support functional articular cartilage formation. However, they have mostly failed to enhance the terminal stage of chondrogenic differentiation, leading to scar tissue formation after the operation. Growth factors substantially regulate cartilage regeneration by acting on receptors to trigger intracellular signaling and cell recruitment for tissue regeneration. In this study, we investigated the effect of recombinant insulin-like growth factor 1 (rIGF-1), loaded in fibrin microbeads (FibIGF1), on cartilage regeneration. rIGF-1-loaded fibrin microbeads were injected into full-thickness cartilage defects in the knees of goats. The stability, integration, and quality of tissue repair were evaluated at 1 and 6 months by gross morphology, histology, and collagen type II staining. The in vivo results showed that compared to plain fibrin samples, particularly at 6 months, FibIGF1 improved the functional cartilage formation, confirmed through gross morphology, histology, and collagen type II immunostaining. FibIGF1 could be a promising candidate for cartilage repair in the clinic.
| Item Type: | Article |
|---|---|
| Funders: | Swiss National Grant, Innosuisse, Bioimaging and Optics Platform of EPFL, ExcellGene for protein production |
| Uncontrolled Keywords: | Articular cartilage; Functional tissue regeneration; Insulin-like growth factor 1; Fibrin |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine > Orthopaedic Surgery Department Faculty of Medicine > Surgery Department Deputy Vice Chancellor (Research & Innovation) Office > Nanotechnology & Catalysis Research Centre |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 20 Oct 2025 14:09 |
| Last Modified: | 20 Oct 2025 14:09 |
| URI: | http://eprints.um.edu.my/id/eprint/48079 |
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