Konda, S. K. and Kanuri, A. K. and Chennuri, B. K. and Anjum, R. and Trivedi, R. and Patlola, M. and Yamini, S. and Bhoomandla, S. (2025) Novel Isoxazole Functionalized Quinazolinone Derivatives and Their Anticancer Activity. Russian Journal of General Chemistry, 95 (1). pp. 146-154. ISSN 1070-3632, DOI https://doi.org/10.1134/S1070363224611128.
Full text not available from this repository.Abstract
AbstractA series of novel isoxazole functionalized quinazolinone derivatives was prepared by hydrolysis of 2-amino-6-(trifluoromethyl)benzonitrile to 2-amino-6-(trifluoromethyl)benzoic acid, followed by the reaction with phenyl isothiocyanate to get 2-mercapto-3-phenyl-5-(trifluoromethyl)quinazolin-4(3H)-one, which was further alkylated with propargyl bromide to obtain propargylated quinazolinone derivatives. Terminal propargyl group was reacted with various substituted benzaldehyde oximes in the presence of strong base to get isoxazole substituted quinazolinone derivatives. All the final compounds evaluated for anticancer activity against four human cancer cell lines such as HeLa, COLO 205, HepG2, MCF7 and promising compounds were revealed.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | quinazolinone; propargylation; isoxazole; anticancer activity |
| Subjects: | Q Science > QD Chemistry R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Pharmacy > Department of Pharmaceutical Technology |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 23 Apr 2025 01:09 |
| Last Modified: | 23 Apr 2025 01:09 |
| URI: | http://eprints.um.edu.my/id/eprint/48035 |
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