Ang, Swee Hung and Lim, Lee-Ling and Mustapha, Feisul Idzwan and Ahmad, Eliana and Rampal, Sanjay (2025) Association between sex, age, temporal trends, and glycemic control of 221,769 adults with type 2 diabetes in a multi-ethnic middle-income Asian country. Diabetes Research and Clinical Practice, 220. p. 111976. ISSN 0168-8227, DOI https://doi.org/10.1016/j.diabres.2024.111976.
Full text not available from this repository.Abstract
Aims: We examined the association between sex, age, temporal trends, and glycemic control among people with type 2 diabetes (T2D) in a multi-ethnic middle-income Asian country. Methods: Using the National Diabetes Registry (2011-2020), we analyzed data for 221,769 adult Malaysians with T2D. We used quantile regressions to estimate the association of sex, age, and their interaction on HbA1c levels at the 5th, 50th, and 95th percentile and logistic regression to estimate the odds of good control (HbA1c < 7 %). Results: The participants were Malays (61.8 %), females (59.3 %), and aged 50-69 years (63.5 %). The median (interquartile range IQR]) HbA1c was 7.2 % (6.4 %, 8.9 %) for males and 7.3 % (6.4 %, 9.0 %) for females. The prevalence of good control was 42.8 % for males and 41.8 % for females. Glycemic control improved from 2011 to 2020 for both females and males above 40. Control significantly improved with age among both sexes. However, females had increasingly better control than men with increasing age (P Heterogeneity < 0.001). The adjusted odds (95 % CI) of good control comparing females to males at 30, 50, and 70 years was 0.90 (0.81, 0.99), 0.93 (0.90, 0.97), and 1.12 (1.08, 1.16) respectively. Conclusions: A more aggressive approach to type 2 diabetes management is needed for both sexes, targeting especially the younger age groups, to improve glycemic control and reduce diabetes burden.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Education, Malaysia (IF076-2019) |
| Uncontrolled Keywords: | Type 2 diabetes; Sex; Age; Glycemic control; Primary care |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine > Medicine Department Faculty of Medicine > Social & Preventive Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 26 May 2025 01:27 |
| Last Modified: | 26 May 2025 01:27 |
| URI: | http://eprints.um.edu.my/id/eprint/48019 |
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