Salazar, Jaime Jimenez and Mirza, Fatim Tahirah and Uzzaman, Md Nazim and Shunmugam, Ranita Hisham and Shazana, Nik Zawani and Pinnock, Hilary and Hirani, Nikhil and Rabinovich, Roberto A. (2025) Characteristics of pulmonary rehabilitation programs and their effects on exercise capacity and health related quality of life (HRQoL) in patients with interstitial lung disease: A systematic review and meta-analysis. Respiratory Medicine, 237. p. 107936. ISSN 0954-6111, DOI https://doi.org/10.1016/j.rmed.2024.107936.
Full text not available from this repository.Abstract
Background: Interstitial Lung Disease (ILD) is characterized by dyspnoea, reduced exercise capacity and poor health related quality of life (HRQoL). The evidence to support the benefits of pulmonary rehabilitation (PR) on exercise capacity (EC) and HRQoL in this population is still limited. We aimed to determine the effect of the different PR components on exercise capacity and HRQoL in patients with ILD. Methods: We searched five databases (January 1990 to August 2024) using Population: ILD patients; Intervention: PR; Comparison: no PR; Outcomes: exercise capacity (e.g., 6-min walk test 6MWT] and HRQoL (e.g., St George's respiratory questionnaire SGRQ]); Study type: randomised controlled trials (RCT). We used Cochrane risk-of-bias tool and GRADE to rate the quality of the evidence. Findings: We identified 11 RCTs (476 ILD patients; 8 countries). 10 studies provided data for exercise capacity (6MWD) and 7 studies for HRQoL (SGRQ). Both 6MWD and SGRQ improved >= their respective m & iacute;nimum clinically-important difference of 45m and 7 units respectively, in studies where PR programme was i) >8 weeks (n = 5) 6MWD: MD 58m, 95 % CI 37 to 79, p < 0.00001; SGRQ: MD -9.7, 95 % CI -12.6 to -6.7, p < 0.00001], ii) fully supervised 6MWD (n = 5): MD 53.6m, 95 % CI 39 to 68, p < 0.00001; SGRQ (n = 2): MD -9.38, 95 % CI -12.93 to -5.84, p < 0.00001] and iii) incorporated high-intensity interval training (HIIT) (n = 2) 6MWD: MD 77m, 95 % CI 45 to 109, p < 0.00001; SGRQ: MD -10.3, 95 % CI -13.7 to -6.9, p < 0.00001] Interpretation: PR programs of >8 weeks, fully supervised and incorporated HIIT had a better clinical impact on EC and HRQoL.
| Item Type: | Article |
|---|---|
| Funders: | Agencia Nacional de Investigacion y Desarrollo de Chile (ANID), Programa Becas Chile de Doctorado en el Extranjero, Convocatoria 2019, folio (72200060) |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Arts and Social Sciences > Department of Library and Information Sience |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 26 May 2025 01:35 |
| Last Modified: | 26 May 2025 01:35 |
| URI: | http://eprints.um.edu.my/id/eprint/48015 |
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