Thorat, B. R. and Mali, S. N. and Shah, Umang and Garg, A. and Agrawal, R. and Arvindekar, S. A. and Cruz, J. N. and de Oliveira, M. Santana and Shaik, A. B. and Lokesh, B. V. S. (2025) Hydrazide-Hydrazone derivatives and their antitubercular activity. Russian Journal of Bioorganic Chemistry, 51 (1). pp. 35-52. ISSN 1068-1620, DOI https://doi.org/10.1134/S1068162025010054.
Full text not available from this repository.Abstract
This review aims to evaluate the mechanisms of action of current and emerging anti-TB drugs and molecules, emphasizing hydrazone functionality. Hydrazone compounds, featuring an azomethine group (R-1-HN-N=CR2R3), exhibit potent anti-TB and broad-spectrum anti-infective properties. It includes the synthesis and biological testing of hydrazide-hydrazones, with a focus on their anti-TB activities reported in the literature. It highlights promising candidates for future anti-TB therapies, underscoring hydrazones' role as a crucial pharmacophore in drug design against tuberculosis and other infectious diseases. This review summarizes pivotal findings in the development of hydrazone-based compounds, contributing to the ongoing search for effective anti-infective agents.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Tuberculosis; Hydrazide-hydrazones; Mycobacterium tuberculosis resistance |
| Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology |
| Divisions: | Faculty of Pharmacy |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 02 Oct 2025 08:17 |
| Last Modified: | 02 Oct 2025 08:17 |
| URI: | http://eprints.um.edu.my/id/eprint/47949 |
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