Hooi, Yuan Teng and Fu, Tzeh Long and Tan, Soon Hao and Ong, Kien Chai and Tan, Chee Yang and Wong, Kum Thong (2025) Neuroinvasion via Peripheral Nerves in Epidemic Viral Encephalitis Caused by Enterovirus, Orthoflavivirus and SARS-Coronavirus. Neuropathology and Applied Neurobiology, 51 (1). e70005. ISSN 0305-1846, DOI https://doi.org/10.1111/nan.70005.
Full text not available from this repository.Abstract
Pathogens invade the central nervous system (CNS) and cause infections either through the haematogenous route or via peripheral nerves. Neuroinvasion via peripheral nerves, involving spinal or cranial somatic nerves, is well-established for certain viral encephalitides such as rabies, herpes simplex encephalitis, and poliomyelitis. Advances in understanding emerging and re-emerging viruses that cause epidemic CNS infections have highlighted the growing importance of peripheral nerve pathways in viral neuroinvasion. This review focuses on epidemic viral encephalitides caused by three groups of RNA viruses, viz., enteroviruses (enterovirus A71 and enterovirus D68), orthoflaviviruses (West Nile virus and Japanese encephalitis virus), and severe acute respiratory syndrome coronaviruses (mainly severe acute respiratory coronavirus-2). We examine evidence supporting the hypothesis that peripheral nerve viral transmission may play an increasingly significant if not more critical role than the haematogenous route in neuroinvasion.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Higher Education high-impact research grant |
| Uncontrolled Keywords: | enterovirus; neurotropic virus; orthoflavivirus; peripheral nerve neuroinvasion; SARS coronavirus |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine Faculty of Medicine > Biomedical Science Department Faculty of Medicine > Pathology Department |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 22 Apr 2025 08:22 |
| Last Modified: | 22 Apr 2025 08:22 |
| URI: | http://eprints.um.edu.my/id/eprint/47935 |
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