Das, Amrita and Sengupta, Prateep and Chatterjee, Shreya and Khanam, Jasmina and Mondal, Pranab Kumar and Romero, Eder Lilia and Manakhov, Anton M. and Thomas, Sabu and Mahmood, Syed and Ghosal, Kajal (2025) Development and Evaluation of Magnetite Loaded Alginate Beads Based Nanocomposite for Enhanced Targeted Analgesic Drug Delivery. Magnetochemistry, 11 (2). p. 14. ISSN 2312-7481, DOI https://doi.org/10.3390/magnetochemistry11020014.
Full text not available from this repository.Abstract
Iron oxide-based nanoparticles, such as magnetic nanoparticles (MNPs), have gained significant attention in the area of drug delivery due to their unique magnetic properties, allowing for precise targeting and controlled release of therapeutic agents. Several successful research studies were reported with combinations of magnetic nanoparticles and polysaccharides such as sodium alginate, chitosan, cellulose, etc. The presented research work is based on synthesising MNPs via the co-precipitation method and their successful encapsulation within alginate beads, serving as a promising drug delivery system for aceclofenac, a model drug. The physical and chemical characteristics of both the prepared magnetite nanoparticles and the aceclofenac-loaded MNPs alginate beads were thoroughly examined using scanning electron microscopy (SEM), high-resolution transmission electron microscopy (HRTEM), Fourier-transform infrared spectroscopy (FTIR), powder X-ray diffraction (PXRD), and vibrating sample magnetometry (VSM). Furthermore, a drug release study was conducted to evaluate the release kinetics of aceclofenac from the prepared MNP alginate beads. The magnetic characteristics of magnetite and MNP beads shed light on the potential application of novel drug delivery systems for magnetically targeted therapeutic interventions. The present research offers valuable insights into the development of magnetic nanoparticle-based drug carriers, paving the way for enhanced drug delivery strategies in the field of pharmaceutical sciences.
| Item Type: | Article |
|---|---|
| Funders: | Department of Science & Technology (India) Science Engineering Research Board (SERB), India (TAR/2020/000088) ; (202223-UGCES-22-GE-WES-F-SJSGC-783) |
| Uncontrolled Keywords: | magnetic nanoparticle; sodium alginate; aceclofenac; vibrating sample magnetometry; targeted therapeutic |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Pharmacy > Department of Pharmaceutical Technology |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 22 Apr 2025 08:43 |
| Last Modified: | 22 Apr 2025 08:43 |
| URI: | http://eprints.um.edu.my/id/eprint/47930 |
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