Sensors in pursuit of personalized radiation medicine

Bradley, D. A. and Taheri, A. and Nawi, S. N. Mat and Ee, Lam Siok and Khandaker, M. U. and Sani, S. F. Abdul and Ihsan, N. S. Mohd Nor and Wong, Jeannie Hsiu Ding (2025) Sensors in pursuit of personalized radiation medicine. Radiation Physics and Chemistry, 231. p. 112602. ISSN 0969-806X, DOI https://doi.org/10.1016/j.radphyschem.2025.112602.

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Abstract

We are developing high spatial resolution radiation-sensitive passive and active insulator sensors, the responses respectively reflecting molecular configuration absorptivity and disruptions, and electron trapping, with readout dependent upon evoked light. Present interest in radiation medicine links with an over-arching aim of providing for the capture of detailed dose data, accessing systems possessing the ability to reflect patient-to-patient variations. In turn, enriched data can link to AI-assisted individualized procedures offering the potential of improvements in therapeutic outcomes. The work builds on prior investigation of the thermoluminescence of 50 mu m graphite foils and Raman analysis of 75 mu m PTFE tape, the latter medium being the focus of current interest. For PTFE the intention herein is to investigate systems of readout that offer an alternative to Raman spectroscopy, investigating photoluminescence- and Fourier Transform Infrared spectroscopy. In use of photoluminescence spectroscopy linear dose sensitivity from a few mGy to in excess of several Gy is found, the lower end being important in encompassing typical penumbral doses and scatter. Additionally, the flexible PTFE tape provides for a comprehensive range of body curvatures. Moreover, unprecedented micron level 2D spatial resolution is obtained from use of laser readout. The tape offers particular advantages, allowing safe and accurate dose assessments in otherwise hard to deal-with situations, including for eyes and skin.

Item Type: Article
Funders: Universiti Malaya
Uncontrolled Keywords: Radiation sensors; Personalized radiation medicine; PTFE dosimeters; Radiotherapy
Subjects: Q Science > QC Physics
Divisions: Faculty of Medicine > Biomedical Imaging Department
Faculty of Science > Department of Physics
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 30 Apr 2025 07:54
Last Modified: 30 Apr 2025 07:54
URI: http://eprints.um.edu.my/id/eprint/47870

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