Nor, Wan Muhammad Farhan Syafiq Bin Wan Mohd and Kwong, Soke Chee and Fuzi, Afiqah Alyaa Md and Said, Nur Akmarina Binti Mohd and Abd Jamil, Amira Hajirah and Lee, Yeong Yeh and Lee, Soo Ching and Lim, Yvonne Ai-Lian and Chung, Ivy (2025) Linking microRNA to metabolic reprogramming and gut microbiota in the pathogenesis of colorectal cancer (Review). International Journal of Molecular Medicine, 55 (3). ISSN 1107-3756, DOI https://doi.org/10.3892/ijmm.2025.5487.
Full text not available from this repository.Abstract
Colorectal cancer (CRC), an emerging public health concern, is one of the leading causes of cancer morbidity and mortality worldwide. An increasing body of evidence shows that dysfunction in metabolic reprogramming is a crucial characteristic of CRC progression. Specifically, metabolic reprogramming abnormalities in glucose, glutamine and lipid metabolism provide the tumour with energy and nutrients to support its rapid cell proliferation and survival. More recently, microRNAs (miRNAs) appear to be involved in the pathogenesis of CRC, including regulatory roles in energy metabolism. In addition, it has been revealed that dysbiosis in CRC might play a key role in impairing the host metabolic reprogramming processes, and while the exact interactions remain unclear, the link may lie with miRNAs. Hence, the aims of the current review include first, to delineate the metabolic reprogramming abnormalities in CRC; second, to explain how miRNAs mediate the aberrant regulations of CRC metabolic pathways; third, linking miRNAs with metabolic abnormalities and dysbiosis in CRC and finally, to discuss the roles of miRNAs as potential biomarkers.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Higher Education, Malaysia [Grant no. LR001B‑2019] |
| Uncontrolled Keywords: | microRNA; Metabolic reprogramming; Colorectal cancer; Glucose metabolism; Lipid metabolism; Glutamine metabolism; Gut microbiota; Microbiome |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Medicine > Department of Pharmacology |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 03 Oct 2025 02:16 |
| Last Modified: | 03 Oct 2025 02:16 |
| URI: | http://eprints.um.edu.my/id/eprint/47842 |
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